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    Ibuprofen from the world leader

      For over 20 years, we have been manufacturing ibuprofen at our FDA-audited, cGMP-certified site in Bishop, Texas – offering a portfolio that delivers unparalleled quality, safety and security of supply. Our wide range includes innovative compounds that slash production time and costs, and faster-acting products that provide rapid pain relief. What’s more, customers benefit from the industry’s most eco-efficient production process, which minimizes waste by avoiding chromium and aluminum salts.

    In-depth expertise: 20 years’ experience manufacturing ibuprofen
    Proven sustainability: The industry’s most eco-efficient ibuprofen production process
    Quality you can rely on: BASF sets standards in compliance, safety and supply security
    Trust in the world leader: 75 years’ experience in generic APIs make BASF a trusted partner

      Leading In Sustainable Ibuprofen Production

      BASF’s ibuprofen production process is an innovative, efficient technology that has revolutionized bulk pharmaceutical manufacturing. It provides an innovative solution to a prevalent problem commonly encountered in bulk API synthesis. Large volumes of aqueous wastes (often containing chromium salts) normally associated with such manufacturing are virtually eliminated. The anhydrous hydrogen fluoride catalyst/solvent is recovered and recycled. Furthermore, no other solvent is needed in any of the reaction steps, simplifying product recovery and minimizing fugitive emissions. The streamlined and continuously improved process makes it a waste-minimizing, environmentally friendly technology. The environmental superiority of the ibuprofen technology at BASF’s Bishop site was recognized with a Kirkpatrick Achievement Award for “outstanding advances in chemical engineering technology” in 1993 and a Presidential Green Chemistry Award in 1997.

      Over 20 Years Of Dedication To Production Of Ibuprofen

      The BASF facility at the Bishop, Texas, site was built in 1991 and began operations on September, 1992. Since then, it has become one of the world’s most significant Ibuprofen plants. The FDA-audited and GMP-compliant production site is part of the OSHA (U.S. Department of Labor's Occupational Safety and Health Administration) Voluntary Protection Program (VPP) and is recognized with the “VPP Star site” status. The VPP recognizes employers and workers in the private industry and federal agencies who have implemented effective safety and health management systems.

      Innovation With Ibuprofen DC 85 – For Direct Compression

      Today BASF produces several ibuprofen grades at its Bishop site including the API for the process-accelerating Ibuprofen DC 85 product, which has been specifically designed for direct compression into tablets. With Ibuprofen DC 85, BASF solved two of the most common industry challenges in direct compression of ibuprofen: persistent sticking to the machinery and the need for high concentration of drug substances. Ibuprofen DC 85 maximizes production speed while minimizing stickiness. The result is a reliable fault-free tableting production with higher output rates. Furthermore, expensive wet granulation and compaction processing steps are not needed, which reduces production costs.

    Product Overview

    Focusing on your needs with platform solutions

    This product overview includes BASF's portfolio of active pharmaceutical ingredients (APIs).

    Technical Information

    Ibuprofen - Technical Information

    Nonsteroidal anti-inflammatory drug, used as analgesic or anti-inflammatory agent.

    Technical Information

    Racemic Ibuprofen Lysinate - Technical Information



    Surface Energy and Physical Properties of Ibuprofen Grades

    In this study, four different grades of Ibuprofen, IBP, (Ibuprofen 25, 50, 70 and 90), representing four crystallization conditions, were chosen for surface energy and physical property measurements. For comparison purpose, the same tests were also conducted on a Kollicoat® IR wet granulated Ibuprofen 70 sample.


    Effective Topical Delivery of Ibuprofen through the Skin

    The ability to effectively deliver non-steroidal anti-inflammatory drugs (NSAIDs) topically and transdermally offers an increased localization of the drug to the site of pain and inflammation, while simultaneously reducing systemic absorption. This ultimately results in more effective treatment for localized pain and inflammation, while reducing the undesired side effects associated with NSAIDs. In this work, the effective topical delivery of ibuprofen is discussed.


    Development of Extended Release Gastroretentive Dosages of Ibuprofen

    There is a continued interest in development of gastroretentive (GR) dosages or floating drug delivery system (FDDS) for extended release to alleviate the side effects associated with drug accumulation. These efforts have led to finding excipients that are stable, less susceptible to moisture, and versatile for the development of pharmaceutical dosages.[…] We investigated polyvinyl alcohol grafted PEG copolymer (e.g. Kollicoat® IR), and its combination with PVA (e.g. Kollicoat® Protect) for their potential use as non-effervescent matrices. Our studies suggest that Kollicoat® Protect outperformed Kollicoat® IR as dry or wet binder, in compressibility and hardness, and for prolonged floating characteristics.In this poster, Kollicoat® Protect has been evaluated as a dry binder for ibuprofen dosages. Kollicoat® Protect thus provides an alternative to other matrices for delivery and design of gastroretentive dosages of ibuprofen. In addition, Kollicoat® Protect for its unique moisture barrier property associated with higher level of PVA, will improve stability of the dosages.

    Application Guideline

    Taste masking of bitter acidic drugs in granules

    ExActConcepts – generic drug formulation for ibuprofen: Increased patient compliance based on taste masking. This formulation concept effectively results in pleasant taste and instant release functionality.