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    Direct compression of solid oral dosage forms – a full range of functional solutions

    Direct compression (DC) is the most economic way to produce a tablet as it is the shortest and most direct way to get from powder mix to final dosage form. BASF offers all functional excipients to successfully develop a DC process for your drug, including key elements like appropriate binder and lubricant.

    Today, direct compression plays a key role in the pharmaceutical industry as the continuing trend towards generics requires manufacturers to design their production processes as efficient as possible. This is what direct compression delivers – formulation components are homogenized by mixing and then directly compressed into the final dosage form.

    However, in order to achieve a robust and lasting dosage form, the to be compressed functional components used in the mix must exhibit good flowability and compressibility. And this factor gets more important in case

    • the amount of functional excipient in the formulation is reduced, i.e. due to a required high drug load, or
    • the drug itself is very poorly flowable or compressible.
    BASFs expertise in functionality enables your high efficiency direct compression process
    All functional components you need for your formulation
    Trusted functionality for a high yield process
    Ready-to-use solutions for projects sensitive to time-to-market

    This is why we offer a range of high to highly effective direct compression binders, disintegrants and lubricants that will provide you all the design space you need for your formulation.

    And if you are working on a project where time-to-market is absolutely critical, we offer specialized ready-to-use premixes for tablets, orally disintegrating tablets and other dosage forms that will enable you to take the fast track towards your direct compression process.

    Your Solution Platform

    Instant & Modified Release

    BASFs rich portfolio of instant and modified release solutions offers an unprecedented range of functionality.

    Discover more about solutions for direct compression 

    Brochure

    Ensuring the precision you need – every time

    Selected key formulation challenges in Instant & Modified Release dosage forms solved with functional excipients from BASF.

    Brochure

    Ludipress® and Ludipress® LCE - The quickest route to direct tableting

    Poster

    Application of Kollidon® VA 64 Fine in roller compaction

    Webinar (on demand)

    Maximizing Roller Compaction Benefits with Proper Excipient Selection

    Whitepaper

    Maximizing Roller Compaction Benefits with the Proper Excipient Selection

    Poster

    Application Related Properties of a New Fast Dispersible Excipient

    Poster

    Tabletting of Non-sticking Ibuprofen DC 85 with Different Disintegrants

    Poster

    Compression Characterization and Lubricant Sensitivity of Orally Disintegrating Tablets Based on Ludiflash®

    Poster

    The application of Kollicoat® MAE 100-55 in sustained release drug development

    Poster

    Evaluating critical quality attributes of direct compressible ibuprofen in a QbD approach

    Poster

    Formulation of rapidly disintegrating tablets with high bitter drug load and high tensile strength

    Portfolio Overview

    Focusing on your needs with platform solutions

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    Looking for application guides, technical and scientific posters, brochures or technical information? Visit our Download Center.

    Formulation Examples of various tablet forms

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