Dry granulation is a great choice to produce solid oral dosage forms if cost and process efficiency are essiential. BASF offers the most effective dry binders available, along with all other functional materials and expertise required to help you develop your process successfully.
Dry granulation for solid oral dosage forms – a full range of functional solutions from BASF
As with direct compression, dry granulation allows dry handling of moisture sensitive active ingredients. It furthermore is another great option if you require an efficient, low-cost tabletting process.
The most common approach for dry granulation is roll compaction, in which a powder blend of all relevant ingredients is compressed between two rotating mills. The resulting ribbons or flakes are fractioned to the desired particle size and then ready for final tablet compression. Roll compaction provides a range of advantages to pharmaceutical manufacturers, including
- Easy and predictable scale-up from development to production
- Continuous process with typically 250kg/hr
- Minimum of floor space required
Next to other ingredients formulated in dry granulated mixtures, key functional component is the right dry binder. It ensures proper agglomeration and tensile strength, and avoids that the granules crumble back to their powderous form
- Most suitable dry binders have high plasticity
- Products with small particle size result in tablets with excellent tensile strength
Learn more about our dry granulation solutions