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    The perfect solution for your skin care challenges



    Formulation Design – Supporting Your Formulation Challenges

    End-to-end excellence: BASF´s functional topical ingredients and expertise to help you overcome critical formulation challenges.

    In the highly competitive, fast-paced business of medicated topical products, development scientists need an intimate knowledge of the physical properties, chemical behavior, specifications, regulatory status, quality attributes and performance of the excipients they use.

    BASF is committed to providing comprehensive, deeply detailed answers to the questions that impact your projects. We can help overcome issues related to product stability, API release and bioavailability, excipient selection and in some cases processing issues. Semi-solid formulation microstructure and its impact on bioavailability and efficacy is a critical topic for brand developers, generic formulators and regulators these days. BASF is committed to understanding how excipient selection and quality can impact microstructure and also product efficacy. On-going internal studies and external partnerships are building our knowledge and expertise in this area. Our experts understand that when it comes to topical formulations, every single element counts. This is why we are committed to best-in-class quality across the ingredients spectrum – whether emulsifiers, gel formers, consistency factors, solvents, actives or emollients.

    Benefits
    Extensive expertise and understanding of topical products
    Fully approved, pharmaceutical-grade products – for peace of mind
    Experience and our analytical knowledge to support formulators worldwide

    Our portfolio is a perfect tool kit to manipulate semi-solo microstructures. Our Kolliphor® emulsifiers, Kolliwax® consistency factors and Kollicream® emollient are the perfect combinations to yield a breadth of formulation aesthetics and drug delivery platforms. Kolliwax® S aids to correct issues with weeping and grainy texture in creams due to low acid values. Moreover, BASF's Pluriol® E series PEGs is especially suitable for the production of ointments with acceptable sensory properties.

    Webinar

    Controlling the Physical Properties and Performance of Semi-solid Formulations

    Semi-solid formulations are in a non-equilibrium state composed of numerous possible microstructures including API polymorphs, surfactant phases, crystalline lipophiles, polymer networks and lipophile-surfactant gel or liquid crystalline phases. The selection of excipients in topical semisolid formulations can determine the structure of microscopic phases that form during processing. The influence of these phases on the formulation physical properties can be observed when measuring viscosity and observing microstructure. Exemplary data will demonstrate how specific excipients were used to modify formulation performance, correct formulations that showed aqueous phase separation or weeping and improve stability.

    Podcast

    The Role of Semisolid Microstructure in Topical Formulation Performance and Functionality

    BASF explains how the selection of excipients in topical semisolid formulations can de- termine the structure of microscopic phases that form during processing.Pharmaceutical Technology magazine recently spoke with Dr. Bozena Michniak-Kohn, Pro fessor and Director of Center for Dermal Research at Rutgers University, and Norman Rich- ardson, Global Technical Development and Marketing Manager, Skin Delivery at BASF, about the importance of semisolid microstructure and the impact they have on the final formulation.

    Whitepaper

    Controlling the physical properties and performance of semi-solid formulations

    Semi-solid formulations are in a non-equilibrium state composed of numerous possible microstructures including API polymorphs, surfactant phases, crystalline lipophiles, polymer networks, and lipophile-surfactant gel or liquid crystalline phases. The selection of excipients in topical semisolid formulations can determine the structure of microscopic phases that form during processing. The influence of these phases on the formulation physical properties can be observed when measuring viscosity and observing microstructure. Exemplary data will demonstrate how specific excipients were used to modify formulation performance, and correct formulations that showed aqueous phase separation or weeping and improve stability.