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    Topical Gels

    BASF offers a broad selection of matrix builders, sensory modifiers and solvents to equip you to be able to produce a wide range of topcial gels.

    Topical gel formulations are of increasing interest in the dermatology industry. Gel formulations are typically transparent or translucent, water-based semisolids with good spreading properties and pleasing aesthetic characteristics.

    Gels derive their consistency and rheological properties from polymers that can swell in water and then interact in such a way as to thicken the water and increase viscosity. Polymers may interact physically, by chain entanglement, or by ionic or hydrophobic/hydrophilic interactions. In each case, the polymers form a matrix that increases the viscosity of the water and allows for (1) physical stabilization and prevention of migration of suspended API crystals, (2) maintenance of product homogeneity throughout the shelf life, (3) clean, no drip, no mess transfer of the product from the primary package to the skin surface and (4) easy spreading and acceptable aesthetics.

    BASF offers broad portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for your gel formulation. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. And by extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance.

    Benefits
    Extensive expertise and understanding of topical products
    Increased patient compliance through characterized sensorial effects
    Meets the highest regulatory and quality requirements
    Broad portfolio of excipients for your ointment formulation

    Some of the key functional excipients offered by BASF include:

    Matrix builders

    Higher molecular weight polyvinylpyrrolidones (such as our Kollidon® 90 F) can be used to increase the viscosity of aqueous media to produce pourable gels. To produce more rigid gels that break on the skin during application poloxamers like our Kolliphor® P188 or Kolliphor® P407 can be used. These generally need to be used at higher levels than other thickening polymers and biopolymers, but they have the advantage of providing some healing, preventative and protective benefits. Another advantage of using poloxamers is that they can act as emulsifiers, stably suspending oils in gels, and also as solubilizers for some APIs.

    Sensory modifiers

    Sometimes gel formulations may have negative sensory or aesthetic properties (e.g. tackiness, etc.). Suspending light lipophilic fluids, such as Kollicream® IPM (isopropyl myristate) or others, can reduce the tack, or generally improve the patient’s experience during application.

    Solvents

    Solubility of APIs in an aqueous matrix can be enhanced by the use of water miscible solvents like propylene glycol (Kollisolv® PG), Triacetin (Kollisolv® GTA), polyethylene glycols (Kollisolv® PEG 300 or Kollisolv® PEG 400), low molecular weight PVPs (Kollidon® 12 PF, Kollidon® 17 PF, Kollidon® 25, or Kollidon® 30) and poloxamers (Kollisolv® P124).

    Discover more on solutions for topical gel formulations

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    Kolliwax® HCO as a High Melting Point Consistency Factor for Topical Applications

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    Film Forming Polymers and Their Functional Use in Topical Dosage Forms

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    Controlling the Physical Properties and Performance of Semi-Solid Formulations through Excipient Selection

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    Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process with Kolliphor ® P 407

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