A disintegrant ensures that a solid oral dosage form quickly breaks into smaller fractions in order to ensure a fast release of the drug. BASF offers disintegrants across a broad range of particle sizes, making any type of desired formulation possible.
Disintegration for solid oral dosage forms – functional solutions from BASF
Disintegrants disperse a dosage form into smaller particles as soon as they reach an aqueous environment, i.e. through swelling. With this breakdown into smaller units, the medium is exposed to more of the active ingredient surface, which then dissolves to be adsorbed. Without the disintegrant, a significant amount of a drug could ultimately pass the body without ever getting to action.
Disintegrants for your formulation need
BASF offers disintegrants with a variety of particle sizes. This choice allows the formulation of effectively disintegrating tablets from very small (i.e. hormone tablets) to large (i.e. supplements). With Kollidon® CL-F, we offer a mid-range particle size disintegrant that combines both strong disintegration functionality with desirable characteristics regarding organoleptics and storage behavior. In addition, we also offer disintegration solutions for orally disintegrating tablets (ODT) that require immediate disintegration in the saliva – including our ready and easy-to-use co-processed Ludiflash®.