Taste masking is necessary when a drug administered orally has an unpleasant taste. Whether you are looking for taste masking in a solid or a liquid dosage form, BASF has a whole range of solutions at hand.
Taste masking for solid and liquid oral dosage forms – our functional solutions
Active ingredients with unpleasant taste are a challenge for formulators. Many drugs being developed are bitter in taste, yet patients and consumers generally expect a pleasant administration experience, regardless of the medication. And on the generic side, there is significant competitive pressure to ensure that your product at least does not fall short in patient compliance, if pharmaceutical marketers want to compete successfully.
Therefore, masking unpleasant taste is key for both solid and liquid dosage forms. BASF offers taste masking solutions for both. And, depending on the bitterness of your drug and the target release profile, you can choose between moderate and maximum taste masking effect.
Solid dosage forms
For tablets and other solid dosage forms, we offer film formers that effectively prevent the active ingredient from reaching the taste buds. If a moderate effect is sufficient, a thin film of Kollicoat® SR 30 D can be applied. If a maximum of effectiveness is required due to a very bitter drug or a minimum of film allowed, our lead taste masking polymer Kollicoat® Smartseal 30 D is the choice to go for.
A special challenge - taste masking for orally disintegrating tablets (ODTs) or other forms based on small particles
The formulation of ODTs or other small particle-based dosage forms can help to improve patient compliance. However, taste masking of pellets or particles is particularly important – and particularly challenging. As confirmed by leading coating experts in the industry, Kollicoat® Smartseal 30 D is the best polymer to tackle this challenge due to its combination of taste masking effectiveness at very low coating levels and non-stickyness during processing.
Liquid dosage forms
For liquid dosage forms, we offer a range of complexation agents like Kollidon® 25 and micelle formers like Kolliphor® RH40 that ensure a pleasant intake.
Kollicoat® Smartseal 30 D – Active Protection
Working with a very bitter active ingredient? Or trying to taste mask small particles?
Try the first aqueous dispersion of a protective polymer. Kollicoat® Smartseal 30 D is the best solution for taste masking protection, and even beyond tablets. It even allows easy and upscalable coating of pellets and particles, without being sticky. And best of all - Kollicoat® Smartseal 30 D does not have a bad smell.
Smart protection from unpleasant taste
Due to the extraordinary stability in the saliva and the specific solubility in gastric juice, Kollicoat® Smartseal 30 D ensures effective protection from unpleasant tastes in the patients mouth and rapid release and onset of action of the active ingredients in the stomach. Kollicoat® Smartseal 30 D hides bitter taste with a significantly reduced coating thickness. For example, it masks the taste of quinine hydrochloride tablets more effectively than other leading protective coatings.