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    Excipients for Drug Formulation Kollicoat® MAE 100-55

    Kollicoat® MAE 100-55

    A complete match – just better. Kollicoat® MAE 100-55 combines two things hard to bring together – it can directly exchange the comparable pH 5.5 enteric release coating polymer in your commercial formulations, and still bring significant handling improvement to your operators because it does not dust at all.

    Kollicoat® MAE 100-55 is the latest addition to our comprehensive portfolio of functional excipients in our Instant & Modified Release Platform. It extends our offer of pH >5.5 enteric release products based on methacrylic acid-ethylacrylate copolymer, providing you even more flexibility.

    Why choose Kollicoat® MAE 100-55
    Direct substitution in commercial enteric release formulations based on methacrylic acid-ethylacrylate copolymer with an opening pH > 5.5
    Easier handling due to dust-free material
    Compliant with respective monographs

    Kollicoat® MAE 100-55
    (non-neutralized powder)

    • Allows direct substitution incommercial formulations
    • Aqueous & organic coating
       

     

    Kollicoat® MAE 100 P
    (pre-neutralized powder)

    • No neutralization required
    • Suitable for extreme weather (powder)
    • Aqueous coating
       

     

    Kollicoat® MAE 30 DP
    (dispersion 30%)

    • Most efficient and cost-effective (not spray-dried)
    • Aqueous coating
    • Not suitable for freezing climate

     

    No more dusting thanks to unique powder particle shape

    The dry powder particles of Kollicoat® MAE 100-55 are larger and thus significantly less dusty than comparable 100-55 coating grades – much easier to work with for your operators:

    Equivalent drug release

    Despite its advantages in handling, Kollicoat® MAE 100-55 provides equivalent drug release as existing comparable coating grades in the market. And this means you can directly introduce it into your commercialized formulations.

    Coated Bupropion HCl tablets (150mg);
    N = 3; 50 rpm;
    Buffer change after 2 h;
    880ml HCl + 20 ml Tri-K phosphate

    Quality and regulatory status

    Kollicoat® MAE 100-55 is produced in Germany under GMP conditions. It complies to respective Ph.Eur., USP-NF, and JPE monographs:

    Discover more about Kollicoat® MAE 100-55

    Flyer

    Kollicoat® MAE 100-55 - a complete match, just better

    Poster

    Kollicoat® MAE: comparing the three different grades regarding preparation and functionality features in enteric release film-coating applications

    Poster

    Soft Gel Enteric Coating Using Methacrylic Acid - Ethyl Acrylate Copolymer

    Poster

    Investigating the effect of partial neutralisation of the polymer on the dissolution characteristics of Kollicoat® MAE 100-55 based coats

    Enteric Release

    Functional solutions for formulations with enteric drug release

    Article

    How To Ensure Reliable Drug Product Quality at Intermediate pH by Using Pre-Neutralized Kollicoat® MAE 100-55

    Brochure

    Ensuring the precision you need – every time

    Portfolio Overview

    Focusing on your needs with platform solutions

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