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    Excipients for Drug Formulation Kollicoat® Smartseal 30 D

    Kollicoat® Smartseal 30 D

      Kollicoat® Smartseal 30 D is the first water based polymer dispersion for taste masking and moisture barrier applications. It was developed to simplify and accelerate aqueous film coating operations and opens new doors for formulating tablet, pellet and particle coatings.

      The best of both worlds

      Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators - but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier, can be achieved with one functional film-forming polymer.

      Kollicoat® Smartseal 30 D is highly impermeable to water vapor, helping preserve the potency of sensitive active ingredients. What’s more, the polymer is highly stable in saliva and specifically soluble in gastric juice. This ensures effective protection from unpleasant tastes in the patient’s mouth and rapid release and onset of action of active ingredients in the stomach.

      As an aqueous polymer dispersion, Kollicoat® Smartseal 30 D is easy to handle, and convenient to apply. And since it can be used in highly concentrated coating suspensions and at high spray rates, you benefit from reduced process times – and significant cost savings.

    Why choose Kollicoat® Smartseal 30 D?
    Smart protection from unpleasant taste
    Effective sealing against moisture
    Fast release of active ingredients
    Easy and economical film coating

      Applications

      Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators- but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier can be achieved Kollicoat® Smartseal 30 D.

    Moisture protection

    Some active ingredients and certain dosage forms (matrix tablets or formulations with a disintegrant) must be protected from moisture. A protective film coating can help preserve the potency of sensitive active ingredients. This is particularly important during packaging or after dispensing the product.

    Strong sealing against moisture
    Film coatings with a low water vapor permeability can delay the moisture uptake of sensitive cores. Tests on isolated films show that Kollicoat® Smartseal 30 D has a lower water vapor permeability than other leading protective coatings.

     

    Taste masking

    The formulation of orally disintegrating tablets (ODTs) or other applications which are easier to dose and more convenient to apply (such as sprinkles) can help to improve patient compliance. Taste masking of pellets or particles is particularly important - and challenging – in the development of such dosage forms.

    Smart protection from unpleasant taste
    Due to the extraordinary stability in the saliva and the specific solubility in gastric juice, Kollicoat® Smartseal 30 D ensures effective protection from unpleasant tastes in the patients mouth and rapid release and onset of action of the active ingredients in the stomach. Kollicoat® Smartseal 30 D hides bitter taste with a significantly reduced coating thickness. For example, it masks the taste of quinine hydrrochloride tablets more effectively than other leading protective coatings. 

    Easy and economical film coating

    An aqeous dispersion, Kollicoat® Smartseal 30 D is easy to handle and convenient to apply. The low viscosity of Kollicoat® Smartseal 30 D allows the preparation of highly concentrated coating suspensions. And since it can also be used at high spray rates, you benefit from reduced coating times and significant cost savings.

    Kollicoat® Smartseal 30 D – Active Protection

    Breaking new ground in taste masking and moisture protection: Kollicoat Smartseal® 30 D is the first waterbased polymer dispersion for taste masking and moisture barrier applications. It was developed to simplify and accelerate aqueous film coating operations, and opens new doors for formulating tablet, pellet, particle and softgel coatings.

      Product

      Kollicoat® Smartseal 30 D is an aqueous dispersion of a co-polymer comprising methyl methacrylate (MMA) and diethylaminoethyl methacrylate (DEAEMA) in a ratio of 6:4. It also contains macrogol cetostearylether 20 (~0.6%) and sodium laruyl sulfate (~0.8%) as stabilizers and has a solids content of 30%.

      An aqueous polymer dispersion, Kollicoat® Smartseal 30 D is easy to handle and convenient to apply. And since it can be used in highly concentrated coating suspensions and at high spray rates, you benefit from reduced process times - and significant cost savings.

      Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators - but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier can be achieved Kollicoat® Smartseal 30 D.

      Kollicoat® Smartseal 30 D is highly impermeable to water vapor, helping preserve the potency of active ingredients. What's more, the polymer is highly stable in saliva and specifically soluble in gastric juice.

      Discover more on Kollicoat® Smartseal 30 D

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    Kollicoat® Smartseal 30 D

    Technical information

    Kollicoat® Smartseal 30D - Technical Information

    Brochure

    Kollicoat® Smartseal 30 D – Active Protection

    Poster

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    Wherever life takes you - BASF excipients for orally disintegrating tablets

    Webinar (on demand)

    Best Practices to Overcome Softgel Coating Challenges

    Poster

    Effective taste-masking based on a new coating dispersion

    Poster

    Taste Masking with Kollicoat® Smartseal 30 D – Dissolution Studies in Biorelevant Media

    Poster

    Using different coating technologies to apply a Kollicoat® Smartseal 30 based functional coat onto drug layered pellets

    Poster

    Taste masking of crystals by coating with the innovative methacrylate copolymer Kollicoat® Smartseal 30 D

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