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    Kollidon® 90 F – The strongest binder on the market

    A highly effective binder, for use as a stabilizer in oral and topical suspensions, as a thickener, and as a hydrophilizing agent or pore-forming agent in medical plastics.

    Kollidon® 90 F is a soluble high-molecular povidone with highest binding properties within the povidone range. Kollidon® 90 F is the strongest wet-granulation binder on the market. Primarily used as a binder in granules and tablets, it can also be deployed to modify the viscosity of liquid dosage forms, and improve bioavailability of certain poorly soluble actives.

    The adhesive, film-forming, dispersing and thickening properties of the soluble Kollidon® grades are used in tablet production, sugar coating, film coating and in the preparation of other dosage forms. The improvement in the solubility of active ingredients brought about by complexation or association, and the thickening effect find use mainly in the manufacture of liquid presentation forms.

    Tablet binding

    When applied for granulation in high shear mixers or fluid-bed granulators the resulting granules with Kollidon® 90 F are hard, freeflowing with a low proportion of fines. Binding strength is excellent to achieve hard and stable tablets. As Kollidon® 90 F has a higher binding capacity the required quantities are 2% or even less. The high viscosity of binder solutions of Kollidon® 90 F sometimes requires precautions to ensure the granules to be evenly wetted.

    Kollidon® 90 F – The strongest wet-granulation binder on the market
    Consistently high quality for reliable performance and formulation stability
    Suitable for the direct compression of tablets without granulation
    High molecular povidone with a broad range of applications

    Kollidon® 90 F are also suitable for the direct compression of tablets without granulation. This technique requires a certain relative humidity, as the powder mixture must have a certain moisture content to bind properly. If Kollidon® is used in addition to microcrystalline cellulose, it not only makes the tablets harder but also gives them stronger edges. For best results in direct compression, all the excipients should have a certain moisture content. This applies to starch, micro-crystalline cellulose and lactose monohydrate as fillers.

    Kollidon® is also suitable as a binder for modern processes such as fluidized-bed granulation.


    Because of its good solubility in water and alcohol, Kollidon® 90 F can be used as a thickener for aqueous-alcoholic solutions for oral application.

    Stabilizers of suspensions

    Kollidon® 90 F can be used to stabilize oral and topical suspensions with a wide range of active ingredients, e. g. acyclovir, ibuprofen, magaldrate, nystatin, phenytoin, trimethoprim, sulfonamides and antibiotics, as well as sugar-coating suspensions. Combinations of Kollidon® 90 F with Kollidon® CL-M have often given very good results.

    Miscellaneous applications

    Apart from the applications described above, the soluble grades of Kollidon® can be used for the following purposes:

    • Adhesives in adhesive gels, e. g. for dentures
    • Stabilization of nitroglycerin in transdermal systems
    • In controlled release preparations and transdermal systems to regulate the release of active substances
    • Hydrophilization and pore formation in plastics for medical applications, e. g. “hollow fibres”
    • Reduction of the toxicity of certain active substances
    • Cryoprotection, lyophilisation
    • Enzyme stabilization, e. g. in diagnostics
    • Vitamin stabilization

    Food products

    In 1995, soluble polyvinylpyrrolidone (povidone) with k-values of 25 and higher was assigned Europe number E 1201 for use in dietetic tablets, e. g. vitamin and dietaryfibre tablets, and in sweeteners.

    PVP (Polyvinyl pyrrolidone) – An all-round talent with tradition

    PVP has a long tradition at BASF and is one of the most interesting and versatile polymers used in the pharmaceutical industry.

    Technical information

    Soluble Kollidon® grades - Technical Information

    Soluble polyvinylpyrrolidone for the pharmaceutical industry

    Application Guide

    Kollidon® Polyvinylpyrrolidone excipients for the pharmaceutical industry

    This book is intended for all persons in pharmaceutical technology and quality control of drugs.

    Application Guide

    Hot Melt Extrusion with BASF Pharma Polymers - Compendium, 2nd and Enlarged Edition

    The compendium now provides readers with an even better understanding of solid dispersions and the hot-melt extrusion process, and offers even more real-world application data.


    Evaluating various wet binders to gain lactose based agglomerates applicable for orally disintegrating tablet formulations

    The aim of this work was to investigate the performance of various wet binders onto the properties of ODTs based on agglomerates, deriving from a high shear granulation process. Furthermore, the impact of the formulation on the disintegration characteristics was investigated.