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    Kollidon® CL-SF

    The finest grade of water-insoluble crospovidone disintegrant available in the market for small and orally disintegrating tablets. It provides smooth tablet surface and cream-like mouth feel. Kollidon® CL-SF strongly improves tablet hardness and has a strong ability to absorb water.

    Kollidon® CL-SF is the finest BASF grade for disintegration applications. It has advantages when it comes to special applications, for example oral fast dispersible tablets. The main reason is a reliable disintegration power in combination with a very smooth cream-like mouth feel. Due to its strong ability to absorb water, Kollidon® CL-SF is also used as a regular disintegrant in wet granulation processes with large amounts of solvent use. Kollidon® CL-SF has the highest solvent (water/ethanol, etc.) uptake capacity of all crospovidones produced by BASF. Moreover, Kollidon® CL-SF gives rise to fewer defects on the tablet surface after storage. Like soluble products crospovidone improves the bioavailability of some hardly soluble actives ingredients.

    The insoluble grades of Kollidon® (Crospovidone) are manufactured by a polymerization process that yields crosslinked insoluble polyvinylpyrrolidone in the form of a “popcorn” polymer. The polymerisation is performed using an aqueous system. Neither organic solvents nor radical starters are involved at any stage.

    Kollidon® CL-SF - The finest disintegrant on the
    Particularily suitable for small and fast dispersible tablets
    Creation of smooth tablet surfaces and cream-like mouth feel
    Suitable for wet granulation due to its strong ability to absorb water
    Consistently high quality for reliable performance and formulation stability

    The insoluble Kollidon® CL-grades possess a number of useful properties for pharmaceutical products.

    • Improvement of tablet disintegration through predictable swelling without gel-formation
    • Swelling properties paired with particle size distribution make the fine Kollidon® CL-grades work efficiently in fast disintegrating formulations
    • Narrow particle size distributions in conjunction with a high swelling pressure recommends Kollidon® CL-SF as disintegrant for small tablets with low API-concentrations
    • In contrast to other disintegrants the Kollidon® grades improve the release and the bioavailability of drugs through complex formation
    • Kollidon® grades feature selective adsorption of polyphenols by complex formation
    • Kollidon® grades feature selective complex formation with some endotoxins

    PVP (Polyvinyl pyrrolidone) – An all-round talent with tradition

    PVP has a long tradition at BASF and is one of the most interesting and versatile polymers used in the pharmaceutical industry.


    BASF Pharma solutions for Orally Disintegrating Tablets

    ODTs are becoming increasingly popular for various reasons. For the consumer or patient, they offer a much more convenient administration, while healthcare companies can use them to differentiate their offer by creating line extensions. In this webinar you will learn about three approaches to develop an ODT – direct compression, granulation & tableting and ready-to-use - and the pros and cons they offer. We will provide guidance on how to choose the right approach for your project, and will support this with a case study as well as an in-depth look at the selection of specific formulation components.