Direct Compression Sustained Release
Kollidon® SR is a polyvinyl acetate and povidone based matrix retarding agent. It is particularly suitable for manufacturing of pH-independent sustained-release matrix tablets by direct compression or hot melt extrusion. Polyvinyl acetate is a very plastic material that produces a coherent matrix even under low compression forces. When the tablets are introduced into gastric or intestinal fluid, the water soluble povidone is leached out to form pores through which the active ingredient slowly diffuses outwards. Kollidon® SR contains no ionic groups and is therefore inert to drug substances. The sustained-release properties are unaffected by ions or salts.