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    Kolliphor® RH40

    Non-ionic oil-in-water solubilizer and emulsifying agent

    Derived from hydrogenated castor oil and ethylene oxide, Kolliphor® RH40 is used as a non-ionic oil-in-water solubilizer and emulsifying agent. It is particularly suitable for fat-soluble vitamins and demonstrates exceptional chemical stability. This tried-and-trusted solubilizer scored highest on resistance to enzymatic digestion in a study of various surfactants, highlighting its potential to enhance patient safety. Kolliphor® RH40 is widely used in self-emulsifying drug delivery systems (SEDDS) or microemulsifying systems (SMDDS) in combination with a co-solubilizer and/or co-solvent. What’s more, Kolliphor® RH40 is almost tasteless – making it ideal for oral applications.

    Effective solubilization in solid & liquid dosage forms.

    Why choose Kolliphor® RH40?
    Widely used solubilizer, approved by all relevant regulatory bodies
    Particularly suited for aqueous solutions of fat-soluble vitamins
    Chemically stable and practically tasteless – perfect for oral applications
    Suitable for SEDDS and SMDDS

    Technical information

    Kolliphor® RH 40 - Technical Information

    A solubilizer for various hydrophobic APIs, fat-soluble vitamins and essential oils

    Application Guide

    Solubility Enhancement with BASF Pharma Polymers - Solubilizer Compendium

    This book is intended for pharmaceutical technologists in industry and at universities who wish to formulate poorly water-soluble drugs or generally interested in solubility enhancement.

    Application Guide

    Hot Melt Extrusion with BASF Pharma Polymers - Compendium, 2nd and Enlarged Edition

    The compendium now provides readers with an even better understanding of solid dispersions and the hot-melt extrusion process, and offers even more real-world application data.


    Testing of different substances for their dermal penetration enhancement.

    Five substances (i.e. Kolliphor® RH 40) were tested for their influence on the penetration behavior of a lipophilic model drug, flufenamic acid, in excised human skin.


    Suitability of Plasticized Polymers for Hot Melt Extrusion

    This study was designed to investigate the influence of several plasticizers (i.e. Kolliphor® RH 40) on the Tg and the melt viscosity of polymers (Kollidon® VA 64, Kollidon® 12 PF, Kollidon® 17 PF, Kollidon® 30, Kollidon® 90 F, Kollidon® SR.