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    Kolliphor® RH40

    Non-ionic oil-in-water solubilizer and emulsifying agent

    Derived from hydrogenated castor oil and ethylene oxide, Kolliphor® RH40 is used as a non-ionic oil-in-water solubilizer and emulsifying agent. It is particularly suitable for fat-soluble vitamins and demonstrates exceptional chemical stability. This tried-and-trusted solubilizer scored highest on resistance to enzymatic digestion in a study of various surfactants, highlighting its potential to enhance patient safety. Kolliphor® RH40 is widely used in self-emulsifying drug delivery systems (SEDDS) or microemulsifying systems (SMDDS) in combination with a co-solubilizer and/or co-solvent. What’s more, Kolliphor® RH40 is almost tasteless – making it ideal for oral applications.

    Effective solubilization in solid & liquid dosage forms.

    Why choose Kolliphor® RH40?
    Widely used solubilizer, approved by all relevant regulatory bodies
    Particularly suited for aqueous solutions of fat-soluble vitamins
    Chemically stable and practically tasteless – perfect for oral applications
    Suitable for SEDDS and SMDDS

    Technical information

    Kolliphor® RH 40 - Technical Information

    A solubilizer for various hydrophobic APIs, fat-soluble vitamins and essential oils

    Application Guide

    Solubility Enhancement with BASF Pharma Polymers - Solubilizer Compendium

    This book is intended for pharmaceutical technologists in industry and at universities who wish to formulate poorly water-soluble drugs or generally interested in solubility enhancement.

    Application Guide

    Hot Melt Extrusion with BASF Pharma Polymers - Compendium, 2nd and Enlarged Edition

    The compendium now provides readers with an even better understanding of solid dispersions and the hot-melt extrusion process, and offers even more real-world application data.

    Poster

    Testing of different substances for their dermal penetration enhancement.

    Five substances (i.e. Kolliphor® RH 40) were tested for their influence on the penetration behavior of a lipophilic model drug, flufenamic acid, in excised human skin.

    Poster

    Suitability of Plasticized Polymers for Hot Melt Extrusion

    This study was designed to investigate the influence of several plasticizers (i.e. Kolliphor® RH 40) on the Tg and the melt viscosity of polymers (Kollidon® VA 64, Kollidon® 12 PF, Kollidon® 17 PF, Kollidon® 30, Kollidon® 90 F, Kollidon® SR.