A high molecular polyethylene glycol (macrogol) mainly used as solvent for oral, topical and parenteral preparations.
Kollisolv® PEG 8000
Polyethylene glycols (PEGs) have been used in pharmaceutical applications for over 50 years, giving this inactive ingredient a wide acceptance. Kollisolv® PEG 8000 is a high molecular polyethylene glycol (macrogol) mainly used as solvent for oral, topical and parenteral preparations. The high molecular weight PEG is soluble in water and organic solvents such as alcohols. It can be blended with other PEG molecular weights to achieve the desired properties, i.e. viscosity. Kollisolv® PEG 8000 will not become rancid and will not support microbial growth, even in aqueous solutions.
Application in oral liquid formulations
Kollisolv® PEG 8000 is used as complexate with APIs for solubilization and taste masking in liquid formulations.
Application in skin delivery
As consistency factor and viscosity enhancer Kollisolv® PEG 8000 forms anhydrous, hydrophilic ointments in combination with lower molecular weight PEGs. It is also suitable as matrix in suppositories.