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    Kolliwax® GMS II

    A solvent for oral, topical applications, co-emulsifier and low HLB surfactant, structure-building consistency factor for semi-solids and a viscosity enhancer. It also hardens suppository formulations and adjust their melting points.

    Kolliwax® GMS II is a white to slightly yellowish, hydrophilic wax, which is supplied as powder. On the account of its consistency giving characters it is mainly used for the viscosity adjustment in pharmaceutical O/W emulsions.

    Major applications

    Emulsions

    Kolliwax® grades can be used for all kinds of topical pharmaceutical applications such as gels, lotions and creams. All Kolliwax® grades act as consistency factors and co-emulsifiers at the same time. With their amphiphilic structure they will stabilize the surface between oil and water and will help to enhance the viscosity with building up a liquid crystalline network in the water-phase (lamellar structure).

    Kolliwax® is able to stabilize W/O and O/W emulsion and will help top create a unique softness and creaminess in the end application. Kolliwax® GMS II acts as co-emulsifier and low HLB surfactant. It stabilizes the surfactant phases & emulsion droplets. It is suitable for production of emulsions & creams, ointments, gels and foams.

    Consistency factor

    Kolliwax® GMS II is used as structure-building consistency factor for semi-solids. It can mitigate stickiness or greasiness in emulsions, ointments and gels.

    Why choose Kolliwax® GMS II?
    Fully approved, pharmaceutical-grade products – for a peace of mind
    Innovative solutions for better, more stable formulations
    Guaranteed performance across a wide variety of applications

    Solubilization

    Kolliwax® GMS II is used as solvent for oral and topical applications. It is suitable for solutions, liquid suspensions and lipid-based drug delivery systems technologies.

    Softgels

    As co-emulsifier and viscosity enhancer Kolliwax® GMS II is used in capsule fill formulations.

    Suppository mass

    Suppository formulations can be hardened and adjusted in their melting point by the addition of Kolliwax® GMS II.

    Webinar

    Thermal Sintering for Controlled Drug Release of Hydrophilic Drugs

    Proper drug release of high-dose hydrophilic drugs is a challenge for formulators since both the initial drug burst release, as well as the consequent sustained release, need to be controlled. Excipients can provide an answer to drug release challenges when their hydrophobic nature is coupled with thermal sintering. This approach intensifies the retardation of drug release by forming plastic matrices of high mechanical strength, which can withstand dose dumping and achieve controlled release. In this webcast, a formulation expert will: - Discuss BASF’s Kolliwax grades and their suitability for thermal sintering - Describe  how high-dose hydrophilic actives were selected to demonstrate the efficacy of thermal sintering (60-65% w/w) using Kolliwax grades - Present processing parameters to enable customers to reproduce controlled drug release of hydrophilic drugs using thermal sintering