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    Kolliwax® HCO

    Kolliwax® HCO is hydrogenated castor powder for pharmaceutical application used as consistency factor in topical formulations, as lipohphillic lubricant in tablets and capsules and as plasticizer in solid dispersions using spray drying, melt granulation or hot melt extrusion processes. Kolliwax® HCO is particularily suitable for formulation ofsensitive APIs.

    Hydrogenated castor oil (Kolliwax® HCO) is a hard wax with a high melting point used in oral and topical pharmaceutical formulations and is used as a lubricant for tablets and capsules. Furthermore HCO can be used to prepare a sustained release formulation for water soluble APIs (e.g. Alfuzosin-HCL, Aminophyllin, Lithiumcarbonat, Niacin, Sulfanilamid, Theophylline). It can either as lipophilic matrix former or as a coating ingredient. Kolliwax® HCO can be used as a standalone solution as well as in combination with other sustained release polymers. Kolliwax® HCO was formerly known as Cutina® HR PH.

    Topical formulations

    In topical formulations, Kolliwax® HCO can be used as consistency factor to enhance the viscosity of the formulation. The typical concentration at about 0.1-2% hydrogenated castor oil is compatible with most natural vegetable and animal waxes and can therefore be used in combination with fatty alcohols and other consistency factors.

    Why choose Kolliwax® HCO?
    Hard wax with a high melting point for oral and topical formulations
    Innovative solutions for better, more stable formulations
    Compatible with most natural vegetable and animal waxes
    Rigorously tested and verified to the most stringent standards pharmaceutical-grade consistency factor

    Similar to emollients, waxes affect the sensory profile and the stability of a topical formulation. They are solid at ambient temperatures and stabilize emulsions as the viscosity is increased by formation of lamellar structures in oil-in-water formulations. Furthermore Kolliwax® HCO has a special advantage because of its high melting point and is able to support the formulation stability particularly at elevated temperatures.

    Lubricant in tablet and capsule formulations

    Lubricants prevent ingredients from clumping together and from sticking to the tablet punches or capsule filling machine. Lubricants also ensure that tablet formulations and ejection can occur with low friction. Common minerals like talc or silica, and fats, e.g. vegetable stearin, magnesium stearate or stearic acid, are most frequently used lubricants in tablets or hard gelatin capsules. Lubricants are added in small quantities to table or capsule formulations to improve certain processing characteristics.

    In tablet formulations Kolliwax® HCO can be used as a lubricant as an effective alternative to magnesium stearate. Hydrogenated castor oil is compatible to a large number of actives and does not provide a metallic taste. Kolliwax® HCO is particularly suitable for formulation of sensitive APIs.

    Plasticizer in solid dispersions

    In solid dispersions, Kolliwax® HCO is used as plasticizer in solid polymeric matrices. It is suitable for melt granulation, spray drying and hot melt extrusion processes.

    Regulatory Status

    Ph. Eur.: Castor Oil Hydrogenated, USP/NF: Hydrogenated Castor Oil, JP: Hydrogenated Oil

    Webinar

    Thermal Sintering for Controlled Drug Release of Hydrophilic Drugs

    Proper drug release of high-dose hydrophilic drugs is a challenge for formulators since both the initial drug burst release, as well as the consequent sustained release, need to be controlled. Excipients can provide an answer to drug release challenges when their hydrophobic nature is coupled with thermal sintering. This approach intensifies the retardation of drug release by forming plastic matrices of high mechanical strength, which can withstand dose dumping and achieve controlled release. In this webcast, a formulation expert will: - Discuss BASF’s Kolliwax grades and their suitability for thermal sintering - Describe  how high-dose hydrophilic actives were selected to demonstrate the efficacy of thermal sintering (60-65% w/w) using Kolliwax grades - Present processing parameters to enable customers to reproduce controlled drug release of hydrophilic drugs using thermal sintering