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    Kolliwax® SA

    As lipophilic lubricant Kolliwax® SA is the first choice for sensitive acidic APIs. It is commonly also used as viscosity regulator for oil-in-water emulsions and as a pH independent sustained release agent. Kolliwax® SA acts as a plasticizer with included consistency factor in solid dispersions. It hardens suppository formulations and adjust their melting points.

    Major applications

    Emulsions

    Kolliwax® grades can be used for all kinds of topical pharmaceutical applications such as gels, lotions and creams. All Kolliwax® grades act as consistency factors and co-emulsifiers at the same time. With their amphiphilic structure they will stabilize the surface between oil and water and will help to enhance the viscosity with building up a liquid crystalline network in the water-phase (lamellar structure).

    Kolliwax® is able to stabilize W/O and O/W emulsion and will help top create a unique softness and creaminess in the end application. Kolliwax® SA is mainly used as structure-building consistency factor for semi-solids such as creams, emulsions, ointments and gels as well as a viscosity regulator with a higher melting point.

    Lubricant

    Kolliwax® SA is a lipophilic lubricant and the first choice for sensitive acidic APIs. As solid lubricant it is suitable for direct compression, wet granulation and roll compaction of tablets and capsules.

    Plasticizer

    In solid dispersions, Kolliwax® SA also acts as plasticizer with an included consistency factor functionality. It is suitable for melt granulation, spray drying and hot melt extrusion (HME) processes.

    Why choose Kolliwax® SA?
    Fully approved pharmaceutical-grade excipient – for your peace of mind
    Pasticizer with included consistency factor functionality
    Lipophilic lubricant and the first choice for sensitive acidic APIs
    Viscosity regulator with a higher melting point
    Guaranteed performance across a wide variety of applications
    Innovative solutions for better, more stable formulations

    Suppository mass

    Suppository formulations can be hardened and adjusted in their melting point by the addition of Kolliwax® SA.

    Webinar

    Thermal Sintering for Controlled Drug Release of Hydrophilic Drugs

    Proper drug release of high-dose hydrophilic drugs is a challenge for formulators since both the initial drug burst release, as well as the consequent sustained release, need to be controlled. Excipients can provide an answer to drug release challenges when their hydrophobic nature is coupled with thermal sintering. This approach intensifies the retardation of drug release by forming plastic matrices of high mechanical strength, which can withstand dose dumping and achieve controlled release. In this webcast, a formulation expert will: - Discuss BASF’s Kolliwax grades and their suitability for thermal sintering - Describe  how high-dose hydrophilic actives were selected to demonstrate the efficacy of thermal sintering (60-65% w/w) using Kolliwax grades - Present processing parameters to enable customers to reproduce controlled drug release of hydrophilic drugs using thermal sintering