Cookies help us deliver our services. By using our services, you agree to our use of cookies. Learn more.

    The perfect solution for your skin care challenges

    Excipients for Drug Formulation Skin Delivery Platform

    Skin Delivery

    The perfect solution for every skincare challenge

    BASF offers an unparalleled portfolio of excipients for topical formulations, enabling customers to create the ideal skin delivery solution for each and every application. We are committed to maintaining the highest level of quality across the product spectrum. Our range of solubilizers and penetration enhancers supports effective delivery of the target API, which is a key priority when designing any dermatological product. At the same time, we have focused on improving the mildness of formulations. And by extensively analyzing, refining, and enhancing the sensorial effects of each ingredient class, we can help our customers create products that increase patient compliance. In addition, BASF works closely with leading global organizations on the design, evaluation and microstructure of semi-solid formulations.

    Experience and expertise BASF is the global market leader in dermatological ingredients. Our premium solutions are based on 150 years of industry experience in oleochemistry.

    GMP production and regulatory support BASF's pharmaceutical-grade dermatology products satisfy all the relevant regulatory requirements. Our integrated quality management is certified in line with the highest quality standards – providing you with products you can trust.

    Key industry partner, with a broad dermatological ingredients portfolio
    Extensive expertise and understanding of topical products
    Innovative breakthroughs such as improved delivery systems
    Meets the highest regulatory and quality requirements

    Tailored customer service Our in-depth expertise and understanding of the dermatology industry enables us to offer tailored solutions and customized excipients if required.

    BASF pharma solutions for dermal drug delivery

    Transdermal drug delivery is an exciting and challenging area. How can skin permeation be improved? What is the key to drug solubilization in transdermal delivery systems? BASF's Skin Delivery platform seeks to provide understanding, solutions and materials for the delivery of drugs to or through the skin.In this presentation BASF highlights fundamental principles that govern dermal drug delivery for successful product development by using models for dermal drug delivery targeting solubilization and skin penetration.

    Skin Delivery Special Applications

    Thermal sintering for  controlled drug release of hydrophilic drugs

    Proper drug release of high-dose hydrophilic drugs is a challenge for formulators since both the initial drug burst release, as well as the consequent sustained release, need to be controlled. Excipients can provide an answer to drug release challenges when their hydrophobic nature is coupled with thermal sintering. This approach intensifies the retardation of drug release by forming plastic matrices of high mechanical strength, which can withstand dose dumping and achieve controlled release. In this webcast, a formulation expert will: - Discuss BASF’s Kolliwax grades and their suitability for thermal sintering - Describe  how high-dose hydrophilic actives were selected to demonstrate the efficacy of thermal sintering (60-65% w/w) using Kolliwax grades - Present processing parameters to enable customers to reproduce controlled drug release of hydrophilic drugs using thermal sintering

    Understanding the Relationship Between Critical Quality Attributes and the Microstructure of Topical Semi-Solid Formulations.

    In this webcast, formulation experts will discuss challenges associated with formulating topical semi-solid dosage products and suggest approaches to address quality and performance issues.



    The role of semisolid microstructure in topical formulation performance and functionality

    BASF explains how the selection of excipients in topical semisolid formulations can de- termine the structure of microscopic phases that form during processing.Pharmaceutical Technology magazine recently spoke with Dr. Bozena Michniak-Kohn, Pro fessor and Director of Center for Dermal Research at Rutgers University, and Norman Rich- ardson, Global Technical Development and Marketing Manager, Skin Delivery at BASF, about the importance of semisolid microstructure and the impact they have on the final formulation.

    Controlling the physical properties and performance of semi-solid formulations

    Semi-solid formulations are in a non-equilibrium state composed of numerous possible microstructures including API polymorphs, surfactant phases, crystalline lipophiles, polymer networks, and lipophile-surfactant gel or liquid crystalline phases. The selection of excipients in topical semisolid formulations can determine the structure of microscopic phases that form during processing. The influence of these phases on the formulation physical properties can be observed when measuring viscosity and observing microstructure. Exemplary data will demonstrate how specific excipients were used to modify formulation performance, and correct formulations that showed aqueous phase separation or weeping and improve stability.


    AAPS PharmSciTech

    Design and Evaluation of Topical Diclofenac Sodium Gel Using Hot Melt Extrusion Technology as a Continuous Manufacturing Process with Kolliphor ® P407

    The aim of the present context was to develop and evaluate a Kolliphor ® P407-based transdermal gel formulation of diclofenac sodium by hot melt extrusion (HME) technology; central composite design was used to optimize the formulation process. In this study, we have explored first time ever HME as an industrially feasible and continuous manufacturing technology for the manufacturing of gel formulation using Kolliphor ® P407 and Kollisolv ® PEG400 as a gel base.