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    Excipients for Drug Formulation Skin Penetration Enhancement


    Skin Penetration Enhancement

    BASF offers a variety of products that enhance API permeation through the skin.

    The penetration of the API through the barrier of the stratum corneum is one of the challenges for developers of topical products designed for the dermal delivery of drugs through the skin. Numerous methods for achieving this have been and continue to be explored. One well-known approach is to use excipients that can accelerate the passage of API through the stratum corneum by altering the state of the lipids in the stratum corneum or by increasing the solubility of the drug in the stratum corneum. Materials that can do this are often called “penetration enhancers”. Classic examples of potent and broad spectrum penetration enhancers include Azone® and dimethyl sulfoxide, among others.

    The ability of an excipient to accelerate stratum corneum permeation through the skin barrier is dependent on the physico-chemical properties (e.g. melting point, molecular weight, molecular geometry, charge, lipophilicity, etc.) of the API. For new APIs studies may need to be conducted to determine the optimal choice of penetration enhancer and/or full formulation to achieve desired dermal delivery.

    Excipients that have been utilized or explored as penetration enhancers include isopropyl myristate (Kollicream® IPM), decyl oleate (Kollicream® DO), oleyl alcohol (Kollicream® OA), octyldodecanol (Kollicream® OD), propylene glycol (Kollisolv® PG) and triacetin (Kollisolv® GTA). Increasing evidence suggests that cocoyl caprylocaprate (Kollicream® 3C) may also accelerate the permeation of some APIs through the skin.

    Benefits
    Variety of excipients that enhance skin penetration of APIs
    Extensive expertise and understanding of topical products
    Meets the highest regulatory and quality requirements

    Product Overview

    Focusing on your needs with platform solutions

    This brochure presents an overview of our leading-edge products, grouped in the following platforms: Skin Delivery, Solubilization, Instant & Modified Release, and Softgels.

    Webinar

    BASF pharma solutions for dermal drug delivery

    Transdermal drug delivery is an exciting and challenging area. How can skin permeation be improved? What is the key to drug solubilization in transdermal delivery systems? BASF's Skin Delivery platform seeks to provide understanding, solutions and materials for the delivery of drugs to or through the skin.In this presentation BASF highlights fundamental principles that govern dermal drug delivery for successful product development by using models for dermal drug delivery targeting solubilization and skin penetration.

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