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    The perfect solution for your skin care challenges

    Excipients for Drug Formulation Viscosity Enhancement


    Viscosity Enhancement

    BASF offers a variety of products that enhance the viscosity of your topical formulation.

    In creams and lotions the stiffness or viscosity of the formulation plays an important role in (1) the proper extrusion of the product from the primary package, (2) the handling of the formulation during application, (3) the stabilization of the dispersed phase (e.g. oil, water, solids, etc.) in the primary package and (4) maintaining the homogeneous distribution of the API in the package during shelf life.

    Benefits
    Variety of excipients that enhance the viscosity of your formulation
    Extensive expertise and understanding of topical products
    Meets the highest regulatory and quality requirements
    Prooven mildness and sensory performance of BASF excipients

    Microstructures

    Typically the desired viscosity or consistency of creams and lotions is built through the addition of solid fatty alcohols, fatty acids, fatty esters and glycerides (Sometimes these materials are called “waxes”. Without the inclusion of these excipients the emulsion formulation will remain watery and difficult to handle. When mixed with emulsifiers and water these materials organize into microstructures (e.g. lamellar phases, gel phases, crystalline phases, etc.) that extend through the continuous water phase and build stiffness and consistency.

    Control of rheological properties

    The rheological properties of a cream can be controlled by the choice of wax that is utilized, the amount of the wax and the wax and emulsifier ratio.

    Combinations of cetyl and stearyl alcohol for a a soft cream

    One of the most commonly used waxes for topical dermatological creams is cetostearyl alcohol, which is a mixture of cetyl and stearyl alcohols. Combinations of cetyl and stearyl alcohol tend to be more stable than cetyl or stearyl alcohol alone. BASF offers Kolliwax® CSA 50 and Kolliwax® CSA 70, which differ only in the ratio of cetyl and stearyl alcohol. The formulator also has the option to customize ratios or use cetyl and stearyl alcohol alone by using our Kolliwax® CA and Kolliwax® SA. Kolliwax® MA (myristyl alcohol) can be used to create a soft, rapidly melting and fast absorbing cream.

    Other alternatives

    Consistency and stiffness can also be managed by using stearic acid (Kolliwax® S) and glyceryl monostearate or mono- and di- glycerides C16-C18 (Kolliwax® GMS II), as well as Kolliwax® HCO (hydrogenated castor oil).

    Product Overview

    Focusing on your needs with platform solutions

    This brochure presents an overview of our leading-edge products, grouped in the following platforms: Skin Delivery, Solubilization, Instant & Modified Release, and Softgels.

    Podcast

    The role of semisolid microstructure in topical formulation performance and functionality

    BASF explains how the selection of excipients in topical semisolid formulations can de- termine the structure of microscopic phases that form during processing.Pharmaceutical Technology magazine recently spoke with Dr. Bozena Michniak-Kohn, Pro fessor and Director of Center for Dermal Research at Rutgers University, and Norman Rich- ardson, Global Technical Development and Marketing Manager, Skin Delivery at BASF, about the importance of semisolid microstructure and the impact they have on the final formulation.

    Whitepaper

    Controlling the physical properties and performance of semi-solid formulations

    Semi-solid formulations are in a non-equilibrium state composed of numerous possible microstructures including API polymorphs, surfactant phases, crystalline lipophiles, polymer networks, and lipophile-surfactant gel or liquid crystalline phases. The selection of excipients in topical semisolid formulations can determine the structure of microscopic phases that form during processing. The influence of these phases on the formulation physical properties can be observed when measuring viscosity and observing microstructure. Exemplary data will demonstrate how specific excipients were used to modify formulation performance, and correct formulations that showed aqueous phase separation or weeping and improve stability.

    Webinar

    Controlling the physical properties and performance of semi-solid formulations

    Semi-solid formulations are in a non-equilibrium state composed of numerous possible microstructures including API polymorphs, surfactant phases, crystalline lipophiles, polymer networks and lipophile-surfactant gel or liquid crystalline phases. The selection of excipients in topical semisolid formulations can determine the structure of microscopic phases that form during processing. The influence of these phases on the formulation physical properties can be observed when measuring viscosity and observing microstructure. Exemplary data will demonstrate how specific excipients were used to modify formulation performance, correct formulations that showed aqueous phase separation or weeping and improve stability.