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    Excipients for Drug Formulation Solubilization Platform


    Solubilization of poorly soluble active ingredients

    Effective solubilization in solid & liquid dosage forms. The right path for greater solubility and bioavailability.

    Poorly soluble drugs are one of the major challenges pharmaceutical manufacturers are facing. More and more drugs in development exhibit low solubility. At BASF, we offer a comprehensive range of cutting-edge solubilization polymers, and have an unparalleled understanding of the corresponding process technologies. This unique combination means that we can make sure you achieve effective solubilization across a range of dosage forms – particularly in solid dispersions.

    Furthermore, BASF is a highly successful pioneer in the application of hot-melt extrusion technology in pharmaceutical production, which helps you combine effectiveness with cost efficiency.

    Finding the best solubilization solution

    Selecting the right solubilization product and technology for a poorly soluble API often involves a lot of trial and error. But partnering with our experts, you can tap into their extensive solubilization expertise and experience with all key technologies, such as hot-melt extrusion, spray drying, and drug layering. Our experts have access to industry-leading tools such as our high-throughput screening (HTS) robot. This puts them in an excellent position to help customers tackle their solubilization and bioavailability challenges rapidly and efficiently.

    BASF delivers answers to even the toughest solubilization challenges
    Comprehensive functional portfolio for solubiliation in solid & liquid dosage forms
    Innovative excipients for poorly soluble APIs
    Proven performance and safety
    Technology leader for key technologies such as hot-melt extrusion
    High throughput screening service Solu-HTS

    Choose Your Drug Delivery System

    Solid dispersions – a great way to increase the solubility and bioavailability of your drug

    Liquid dispersions, solutions, emulsions & micro emulsions

    overview

    Discover our solubilization solutions

    Solubilization challenges need new ways

    In the Pharmaceutical industry, more than 70% of new drugs developed are poorly water soluble, which means that the human body can hardly adsorb them. This represents one of the major challenges of the industry.
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    Solubilization challenges need new ways

    In the Pharmaceutical industry, more than 70% of new drugs developed are poorly water soluble, which means that the human body can hardly adsorb them. This represents one of the major challenges of the industry.
    //img.youtube.com/vi//hqdefault.jpg

    In Conversation with Andreas Gryczke of BASF

    The Medicine Maker's Charlotte Barker sat down with business leaders and specialists from across the pharmaceutical manufacturing landscape to discuss the latest innovations and trends. Here, Charlotte speaks with Andreas Gryczke from BASF.

    eBooks

    eBook

    The Formulation Complex: Unravelling the challenges and trends in formulation best practice – and why lipids and softgels are leading the way.

    eBook

    The Science of Insolubility: Experts come together to discuss the chemistry of solubility – and the solutions of the future

    Compendium

    Solubility Enhancement with BASF Pharma Polymers - Solubilizer Compendium

    Compendium

    Hot Melt Extrusion with BASF Pharma Polymers - Compendium, 2nd and Enlarged Edition

    Webinars

    Webinar

    Practical Considerations for Overcoming Bioavailability Challenges with LBDDS ...

    Webinar

    Choosing the Proper Dissolution Method When Testing Solubilization Performance

    Webinar

    Twin Screw Wet Granulation for Solubility Enhancement of Poorly Water-Soluble Drugs

    Webinar

    How glass-forming polymers improve bioavailability / Enhanced oral bioavailability with Soluplus® – case study

    Articles

    Pharmaceutical Technology

    Choosing the Proper Dissolution Method when Testing Solubilization Performance of Poorly Soluble Drug Molecules

    The Medicine Maker

    From Brick Dust to Blockbuster? - Self-emulsifying lipids, and other innovative solubilizers and polymers

    European Journal of Pharmaceutics and Biopharmaceutics

    Micro-scale prediction method for API-solubility in polymeric matrices

    Drug Development & Delivery

    EXCIPIENT UPDATE - Soluplus®: An Understanding of Supersaturation From Amorphous Solid Dispersions

    Pharmaceutical Technology

    The advantages and disadvantages of hot-melt extrusion in solid dispersion formulations

    American Pharmaceutical Review

    Challenges and Opportunities in Oral Formulation Development

    Podcasts

    Twin Screw Wet Granulation for Solubility Enhancement of Poorly Water-Soluble Drugs

    Product Overview

    Focusing on your needs with platform solutions

    This brochure presents an overview of our leading-edge products, grouped in the following platforms: Solubilization, Instant and Modified Release, Skin Delivery, Softgels.

    Download Center

    Looking for application guides, technical and scientific posters, brochures or technical Information? Visist our download Center.

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