Cookies help us deliver our services. By using our services, you agree to our use of cookies. Learn more.

Choose a location

    Soluplus®
    For Better Solubility and Bioavailability

    With its excellent capability to form solid solutions, Soluplus® is suitable for innovative processing technologies, such as hot melt extrusion. Soluplus® was awarded with the CPhI Silver Innovation Award in 2010.

    Soluplus® is an innovative excipient that enables new levels of solubility, and bioavailability for poorly soluble active ingredients. Developed specifically for solid solutions, Soluplus® is unique in many ways. Thanks to its high flowability and excellent extrudability, Soluplus® shows superior performance in forming solid solutions, especially in hot melt extrusion processes. This solid solution makes the active pharmaceutical ingredient (API) available in a dissolved state, resulting in improved bioavailability, once in the body. The safety of Soluplus® is documented by a comprehensive range of toxicological data.

    Benefit from the advantages of Soluplus®
    Soluplus® has been designed to solubilize poorly soluble APIs
    Outstanding solubilization properties, especially for poorly soluble APIs
    Enables bioavailability enhancement
    Ideal for hot melt extrusion and all standard granulation techniques
    Market proven solution for unique formulation challenges

    Hot melt extrusion

    Hot melt extrusion technology has become increasingly popular in recent years. Although this technique has been used in the plastics and food industries for decades, it is relatively new in the pharmaceutical industry and only a few drug products manufactured this way are currently available on the market. Hot melt extrusion technology shows numerous benefits over traditional methods, including shorter processing times, environmental advantages due to the elimination of solvents and the more efficient delivery of drugs to patients.

    Great results in hot melt extrusion.

    The high flowability and excellent extrudability of Soluplus® make for first-class results in hot melt extrusion. Soluplus® was specifically designed to solubilize poorly soluble APIs in this innovative production process. Its outstanding ability to form solid solutions and excellent solubilization capabilities, combined in one molecule, distinguish Soluplus® from other molecules that are used to form solid solutions or deployed in hot melt extrusion. However, Soluplus® is not limited to solid solutions formed via hot melt-extrusion, but can also be used as a matrix former in spray drying processes. Furthermore, it can be deployed as a binder in wet or dry granulation and in drug layering. These possibilities, and many others, extend the potential scope of Soluplus®. Formulators can use the new polymer in many different ways to significantly improve solubility and bioavailability.

    Significant improvement in API release.

    Designed specifically for poorly soluble APIs.

     

    Significant improvement in bioavailability.

     

    Results from dissolution tests showed a faster release of the poorly soluble API itraconazole in solid solutions prepared with Soluplus®. Compared to other polymeric matrices, the fastest release was achieved with Soluplus®.

    For example, its solubilization capacity for the poorly soluble carbamazepine, ketoconazole and danazol is much higher compared to well-known surfactants such as Solutol® HS 15 (Kolliphor® HS 15) and Cremophor® RH 40 (Kolliphor® RH 40) in a saturated solution in phosphate buffer (pH 7.0).

    Results showed a considerable improvement in the bioavailability of the poorly soluble API Itraconazole in solid solutions prepared with Soluplus®. The bioavailability study was conducted in beagle dogs.

    Product safety demonstrated by comprehensive toxicological data.

    A wide range of toxicological studies have been performed on Soluplus®, and the safety of the product has been documented in comprehensive studies. Toxicological data can be provided upon request.

    Soluplus in standard processes. 


    Even though Soluplus® was developed for solid solutions, it can be used for other applications too. Besides hot melt extrusion, drug layering and spray drying, it can be also applied as a binder in wet granulation or dry binder in direct compression. With multiple applications like these, you stand to benefit from the solubilization capabilities of Soluplus® while using it in standard processes.

    Discover more about Soluplus®

    Compendium

    Hot Melt Extrusion with BASF Pharma Polymers - Compendium, 2nd and Enlarged Edition

    Compendium

    Solubility Enhancement with BASF Pharma Polymers - Solubilizer Compendium

    Flyer

    Soluplus® - For Better Solubility & Bioavailability

    Technical information

    Soluplus® - Technical Information

    Brochure

    Soluplus® – The Solid Solution: Opening New Doors in Solubilization

    ebook

    The Science of Insolubility: Experts come together to discuss the chemistry of solubility – and the solutions of the future

    ebook

    Formulation Technologies and Excipient Selection: Strategies for Improving Solubility

    ebook

    Current Solubilization Techniques: Insights from the BASF Solubilization Symposium

    Drug Development & Delivery

    EXCIPIENT UPDATE - Soluplus®: An Understanding of Supersaturation From Amorphous Solid Dispersions

    Pharmaceutical Technology

    Bioavailability Enhancement: A Soluplus® case study of itraconazole

    Webinar

    How glass-forming polymers improve bioavailability / Enhanced oral bioavailability with Soluplus® – case study

    Webinar

    Twin Screw Wet Granulation for Solubility Enhancement of Poorly Water-Soluble Drugs

    Podcast

    Twin Screw Wet Granulation for Solubility Enhancement of Poorly Water-Soluble Drugs

    Webinar

    Choosing the Proper Dissolution Method When Testing Solubilization Performance

    Whitepaper

    Choosing the Proper Dissolution Method when Testing Solubilization Performance of Poorly Soluble Drug Molecules

    European Journal of Pharmaceutics and Biopharmaceutics

    Micro-scale prediction method for API-solubility in polymeric matrices

    Pharmaceutical Technology

    The advantages and disadvantages of hot-melt extrusion in solid dispersion formulations

    Poster

    Solubility Enhancement of Poorly Water Soluble Drug Using a Novel Polymeric Solubilizer (Soluplus®)

    Poster

    Solubility Enhancement of Simvastatin with Use of Novel Polymeric Solubilizer Soluplus®

    Product Portfolio Overview

    Focusing on your needs with platform solutions

    Download Center

    Looking for application guides, technical and scientific posters, brochures or technical Information? Visit our Download Center.

    TOP