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    Increase of solubility and bioavailability using spray drying and BASF excipients

    Spray drying is an established technology in the pharmaceutical industry to create amorphous, soluble forms of active ingredients. Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. BASF offers a wide range of functional polymers to choose from, along with all other excipients typically used in the formulation.

    Within the extended solubility improvement toolbox of a formulator, spray drying is an accepted choice due to its market track record and specific advantages. Its capability to form amorphous solid dispersions of poorly soluble drugs, resulting in increased solubility, along with good control over particle size has made it the commercial process for various active ingredients.

    Spray drying with functional BASF polymers
    Significant increase of solubility and bioavailability
    Extensive knowledge in combination of process and excipient functionality
    Robust continuous processing with the right polymer selection

    Forms of spray dried particles

    Importance of process parameters

    In the process, a polymer is dissolved together with the active ingredient in a solvent (aqueous or organic). It is then atomized into droplets, and brought into contact with hot process gas. This causes rapid evaporation of the solvent and formation of solid particles, which are then filtered and dried.

    The steps can be summarized as follows:

    1. Manufacture and atomization of the liquid.
    2. Drying and formation of particle morphology within the spray tower.
    3. Filtration, post drying, cooling and packaging of the powder.

    Solubilization Platform

    Effective solubilization for solid & liquid dosage forms

    Choosing the right excipients

    Next to the spray drying process parameters, the selection of an appropriate polymer to form the solid particles together with the drug plays a crucial role for the resulting solubility & bioavailability improvement.

    However choosing the right excipient for a specific active ingredient is still a matter of experience and trial and error. We offer an extensive range of highly functional solubilizers, matrix polymers and additional complementary excipients – together with our teams unmatched expertise of excipient functionality, we enable you to identify the right solubilization solution for your formulation to be spray dried.

    Learn more about our spray drying solutions

    Compendium

    Solubility Enhancement with BASF Pharma Polymers - Solubilizer Compendium

    eBook

    Current Solubilization Techniques: Insights from the BASF Solubilization Symposium

    eBook

    Formulation Technologies and Excipient Selection: Strategies for Improving Solubility

    eBook

    The Science of Insolubility: Experts come together to discuss the chemistry of of solubility – and the solutions of the future

    American Pharmaceutical Review

    Challenges and Opportunities in Oral Formulation Development

    Poster

    Evaluation of the polymer Soluplus® for spray-dried dispersions of poorly soluble compounds.

    Poster

    The impact of reprocessing on typical physicochemical attributes and particle properties of spray dried Kollidon® VA64

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    Focusing on your needs with platform solutions

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