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    Solid dispersions – a great way to increase the solubility and bioavailability of your drug

    In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility and bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

    Increasing number of poorly soluble drugs
    The pharmaceutical industry is facing the challenge of having more and more poorly soluble drug molecules that have to be developed into dosage forms so that high and reliable drug absorption can be guaranteed on being administered to patients. Different approaches are possible to overcome solubility issues. Solid dispersions are one of them. It seeks to disperse the drug in a carrier and create a solid system that can be processed into a final dosage form.

    Benefit from our combination of comprehensive portfolio & technology expertise
    Industry leading expertise in solid dispersions
    Broad portfolio covering every functionality required
    Functional polymers for all major processing technologies

    Increasing number of poorly soluble drugs
    The pharmaceutical industry is facing the challenge of having more and more poorly soluble drug molecules that have to be developed into dosage forms so that high and reliable drug absorption can be guaranteed on being administered to patients. Different approaches are possible to overcome solubility issues. Solid dispersions are one of them. It seeks to disperse the drug in a carrier and create a solid system that can be processed into a final dosage form.

    Characteristics of solid dispersions
    There several types of solid dispersions, nevertheless typical characteristics are a reduced particle size of the active ingredient, improved wetting, reduced agglomeration, changes in the physical state of the drug and possibly dispersion on a molecular level. The physical state of the solid dispersion will depend on the physicochemical properties of the carrier and the drug, the drug-carrier interactions and the preparation method.

    Typical processes to create solid dispersions
    Solid dispersions can be produced using various technologies. Some of the most relevant are spray drying, hot melt extrusion and freeze drying, with all of them having their pro's and con's. For in depth comparison and further details we have put together a compendium discussing solid dispersions, different processing technologies and hot melt extrusion in particular. Hot melt extrusion compendium

    At BASF, we understand that using a solid dispersion approach is one out of various approaches to achieve sufficient solubility & bioavailability for your active ingredient. We offer the most comprehensive portfolio of functional solutions in combination with extensive processing know-how. This allows us to help you to find the optimal solution for your drug, combining sufficient solubility & bioavailability with economic & efficient production processes.

    Product Overview

    Focusing on your needs with platform solutions

    This brochure presents an overview of our leading-edge products, grouped in the following platforms: Solubilization, Instant and Modified Release, Skin Delivery, and Softgels.

    Article: European Journal of Pharmaceutics and Biopharmaceutics

    Micro-scale prediction method for API-solubility in polymeric matrices

    A new predictive micro-scale solubility and process model for amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is presented.

    Webinar

    How glass-forming polymers improve bioavailability / Enhanced oral bioavailability with Soluplus® – case study

    How glass-forming polymers improve bioavailability Polymers are essential components of oral solid dosage forms and used as binders, disintegrants or coatings. Given the increase in poorly water-soluble drugs, not only well-known but also specifically designed polymers (e.g. Soluplus®) can be used to improve both drug dissolution and bioavailability. Solid dispersions – embedded drug molecules at a molecularly dispersed state into an amorphous polymer – have shown superior bioavailability in comparison to other drug delivery systems. This webinar introduces the specific process technologies, namely hot melt extrusion or spray-drying, and the polymeric excipients available in the BASF portfolio to develop stable solid solutions. Enhanced oral bioavailability with Soluplus® – case study Soluplus® based solid solutions increase the solubility and oral bioavailability of poorly soluble active ingredients. Results from an in-vivo study in dogs with itraconazole showed a more than two-fold increase in oral bioavailability of a Soluplus® based formulation compared to the commercially available drug product. The Presentation explains what is special about Soluplus® and gives recommendations for in-vitro dissolution testing and the formulation of a quickly disintegrating tablet.

    Article

    The advantages and disadvantages of hot-melt extrusion in solid dispersion formulations

    Solid dispersions represent a promising formulation approach for overcoming today's major challenge in pharmaceutical formulation development: poorly soluble and poorly permeable active pharmaceutical ingredients (APIs). Solid dispersions can be obtained using different processes; however, hot-melt extrusion (HME) is extremely suitable for this purpose.

    Article

    EXCIPIENT UPDATE - Soluplus®: An Understanding of Supersaturation From Amorphous Solid Dispersions

    Amorphous Solid Dispersions (ASDs) have been widely accepted as a desired solution for enhancing solubility and bioavailability of poorly soluble drugs. 1 With a trend in increased number of poorly soluble new chemical entities (NCEs), the industry is adapting non-conventional formulation technologies, exploiting the existing polymers, and exploring innovative ones to expedite drug development. 2 However, the applicability of those polymers in such technologies has also created new challenges associated with processing and manufacturing or thermal instability, such as hot melt extrusion and Kinetisol®, or residual solvents, such as spray drying and co-precipitation.

    Platform Solutions

    Solubilization Platform

    Effective solubilization in solid & liquid dosage forms. The right path for greater solubility and bioavailability.

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