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    Plasticizers for Solid Dispersions

    BASF offers a comprehensive portfolio of plasticizing substances for solid dispersion matrices. BASF plasticizers fulfil the requirements of most important monographs and are based on various chemistries and molecular weights.

    The glass transition temperature (Tg) is an important parameter to consider when working with polymeric films or matrices like e.g. in solid dispersion applications or film coating. It defines the temperature when an amorphous polymer changes from a hard and relatively brittle "glassy" state into a deformable state and vice versa. The glass transition temperature of each polymer can be reduced by introducing plasticizing substances that impact the interaction of polymer chains. In the area of solid dispersions such a reduction of glass transition temperature might be necessary for e.g. decreasing the processing temperature in a hot melt extrusion process or reducing the brittleness of the final solid dispersion.

    BASF offers a comprehensive portfolio of plasticizing substances for solid dispersion matrices. BASF plasticizers fulfil the requirements of most important monographs and are based on various chemistries and molecular weights. The broad portfolio ranges from polymeric plasticizers like polyethylene glycols (Kollisolv® PEG 300 and Kollisolv® PEG 400) and poloxamers (Kolliphor® P 188 and Kolliphor® P 407) towards low molecular weight species like triacetin (Kollisolv® GTA) or stearyl alcohol (Kolliwax® SA).

    Figure: Tg of pure solid dispersion matrix polymers (n) in comparision with to polymers with 10% plasticizer Kolliphor® P 188 (n), Kolliphor® RH 40 (n), PEG 1500 (n) or Kolliphor® TPGS (n) (extrudates and films (*), 9:1 w/w%).

    BASF´s comprehensive plasticizer portfolio
    Various chemistries for compatibility with different matrices
    High and low molecular weight plasticizers
    Liquid and solid plasticizers
    In line with standard regulatory requirements

    Product Overview

    Focusing on your needs with platform solutions

    This brochure presents an overview of our leading-edge products, grouped in the following platforms: Solubilization, Softgels, Instant & Modified Release, and Skin Delivery.

    Application Guide

    Solubility Enhancement with Pharma Polymers

    The compendium now provides readers with an even better understanding of solid dispersions and the hot-melt extrusion process, and offers even more real-world application data.

    Application Guide

    Hot Melt Extrusion with BASF Pharma Polymers

    This book is intended for pharmaceutical technologists in industry and at universities who wish to formulate poorly water-soluble drugs or generally interested in solubility enhancement.