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    Sustained release



    Functional solutions for formulations with sustained drug release

    Sustained release profiles allow tailored dosing of the active ingredient over an extended period of time up to 24 hours. Common ways to achieve such release rates are the use of film coating, a sustained release matrix or sustained release drug-loaded granules. BASF offers powerful excipients that provide almost endless design space for sustained release formulations.

    One of the major challenges for marketers of pharmaceutical products is the compliance of the patient. When a drug needs to be adminstered several times a day, patients acceptance of the medication can decrease considerably, leaving the risk of insufficient treatment.

    A common solution to increase medication acceptance in this case is to formulate the drug in a dosage form that releases the active ingredient steadily over an extended period of time. Such sustained release formulations have gained considerable traction in the pharmaceutical industry, and will continue to be a major tool to improve the patients experience for existing and new drugs. It also represents an attractive opportunity for companies and formulators in particular to differentiate their potentially generic product from standard instant release versions in the market.

    We offer a distinct set of highly functional materials that allow you to flexibly design your desired sustained release profiles.

    Sustained release solutions from BASF
    Increased patient
    compliance
    Differentation of your dosage form
    in the market
    Efficient processing, reducing ecological
    footprint

    Webinar

    Product innovation on modified release coatings (sustained release and enteric coatings)

    Developing modified coatings that produce a reliable and stable release is still a challenge. Only a few polymers - polyvinylacetate, ethylcellulose and methacrylates - are suitable for this purpose and have very different characteristics. In this webinar, you will gain an in-depth knowledge about the relevant requirements for modified release coatings and how they can be fulfilled, for instance by choosing a suitable polymer, the proper formulation and the best process parameters.

    Webinar

    Sustained-Release Formulation: Overcoming Key Challenges Like Alcohol-Induced Dose Dumping

    In this webinar, experts will outline major formulation approaches for sustained release, explain regulatory requirements regarding alcohol-induced dose dumping and the pharma industry’s activities to cope with these guidelines, and share the new research findings, which offer a formulation solution that complies to these requirements while delivering effective sustained-release dissolution.

    Webinar

    Thermal Sintering for  Controlled Drug Release of Hydrophilic Drugs

    Proper drug release of high-dose hydrophilic drugs is a challenge for formulators since both the initial drug burst release, as well as the consequent sustained release, need to be controlled. Excipients can provide an answer to drug release challenges when their hydrophobic nature is coupled with thermal sintering. This approach intensifies the retardation of drug release by forming plastic matrices of high mechanical strength, which can withstand dose dumping and achieve controlled release. In this webcast, a formulation expert will: - Discuss BASF’s Kolliwax grades and their suitability for thermal sintering - Describe  how high-dose hydrophilic actives were selected to demonstrate the efficacy of thermal sintering (60-65% w/w) using Kolliwax grades - Present processing parameters to enable customers to reproduce controlled drug release of hydrophilic drugs using thermal sintering

    Article

    Controlled release: a new paradigm with polyvinyl acetate polymer

    Controlled release (CR) has been a subject of continued interest, and the pharma industry is taking a closer look into release profiles of drugs because of risk factors associated with early release (dose dumping) before being delivered to intended sites to achieve the desired efficacy, and to overcome toxicity and drug abuse issues. The latter has become more challenging, especially in controlled delivery of opioids in pain management. Nonetheless, the former one is also poorly understood because of complexity associated with the mechanism of controlled release from a particular dosage.

    Poster

    Alcohol-Induced Dose Dumping Resistant Matrix Tablets with Kollidon® SR

    The purpose of this study is to investigated the suitability of Kollidon® SR in combination with polymers of different chemistry for manufacturing of sustained release solid oral dosage forms of APIs required alcohol induced dose-dumping resistance.

    ebook

    Overcoming Challenges in Sustained-Release Drug Formulation

    In this eBook, experts review unique considerations for formulating sustained-release drug products, including conflicting regulatory guidances, excipient selection, and balancing human physiological factors with physicochemical properties of the formulated drug.