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    Transdermal Patches

    BASF offers a variety of polymeric matrix formers and solvents suitable for transdermal patch formulations.

    Adhesive transdermal patches are a growing technology for API delivery. Transdermal patches (TDDS) can take a variety of forms (e.g. simple drug-in-adhesive, multilayered, reservoir, etc.). The key advantages of this dosage form are: (1) Frequency of patient dosing may be reduced, due to prolonged or controlled API delivery, (2) API can be delivered when oral application is not possible, (3) Patches can be designed to deliver drugs at a specific controlled rate, (4) Patch application is painless and with minimal aesthetic negatives, as compared to injections or poor tasting oral formulations, (5) patches are easily applied to patients who resist oral dosage forms (e.g. children, elderly, disabled, etc.).

    Functional excipients required for successful design of transdermal patches includes:

    Polymeric matrix formers

    In transdermal patches the API must remain solubilized in the adhesive or polymeric matrix that is placed against the skin surface. BASF has several excipients that are used to form API-solubilizing matrices in transdermal patches (e.g. Kollidon® VA64, Soluplus®, Kollidon® CL, etc.)
     

    Solvents

    Low molecular weight polyvinylpyrrolidones (Kollidon® 12, Kollidon® 17, Kollidon® 25 and Kollidon® 30), copovidone (Kollidon® VA64), Triacetin (Kollisolv® GTA), and others, can be used to prevent the recrystallization of APIs in TDDS patches. A variety of our emulsifiers (Kolliphor® product rang) can also be used as solubilizers of APIs in patches.

    Microneedle Patches

    Microneedle patches are also being explored for the delivery of large molecules across the stratum corneum barrier. The various forms of microneedles include coated solid microneedles, hollow solid microneedles and soluble microneedles. BASF has polymers that are being explored for use in microneedle technologies.

    Benefits
    Variety of excipients suitable for API-solubilizing matrices in transdermal patches
    Wide range of solubilizers and solvents used in transdermal patches
    BASF offers polymers that are being explored for use in microneedle technologies.
    Extensive expertise and understanding of topical products
    Meets the highest regulatory and quality requirements

    Product Overview

    Focusing on your needs with platform solutions

    This brochure also features BASF's functional solutions for transdermal patches.

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