BASF offers a variety of polymeric matrix formers and solvents suitable for transdermal patch formulations.
Adhesive transdermal patches are a growing technology for API delivery. Transdermal patches (TDDS) can take a variety of forms (e.g. simple drug-in-adhesive, multilayered, reservoir, etc.). The key advantages of this dosage form are: (1) Frequency of patient dosing may be reduced, due to prolonged or controlled API delivery, (2) API can be delivered when oral application is not possible, (3) Patches can be designed to deliver drugs at a specific controlled rate, (4) Patch application is painless and with minimal aesthetic negatives, as compared to injections or poor tasting oral formulations, (5) patches are easily applied to patients who resist oral dosage forms (e.g. children, elderly, disabled, etc.).
Functional excipients required for successful design of transdermal patches includes:
Microneedle patches are also being explored for the delivery of large molecules across the stratum corneum barrier. The various forms of microneedles include coated solid microneedles, hollow solid microneedles and soluble microneedles. BASF has polymers that are being explored for use in microneedle technologies.