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Excipients for Drug Formulation
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Excipients for Drug Formulation
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Excipients for Drug Formulation

Create the ideal skin delivery
solution for your cream or emulsion

Our skin delivery solutions

Global
Excipients for Drug Formulation

Solutions for Creams & Emulsions

BASF offers a broad selection of oils, emulsifiers, viscosity enhancers and solvents to equip the formulator to be able to produce a wide range of lotions, creams and gel emulsions.

Creams and emulsions are the most diverse and widely used dosage forms for topical dermatological applications. They are two-phase systems typically containing hydrophilic ingredient in an aqueous phase and lipophilic ingredients in an oil phase. In order for topical emulsions to function effectively they require certain functional excipients.

BASF offers an unparalleled portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for your cream or emulsion. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. And by extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance. Our range of solubilizers and penetration enhancers support effective delivery of the target API – the number-one priority when designing any dermatological product

Benefits

  • Extensive expertise and understanding of topical products
  • Increased patient compliance through characterized sensorial effects
  • High quality products for maximum mildness
  • Innovative breakthroughs such as improved delivery systems
  • Meets the highest regulatory and quality requirements

Oils or Emollients

Lipophilic fluids that can (a) solubilize lipophilic APIs, (b) form films on the skin that provide a barrier to water loss, (c) provide pleasing sensorial cues during and after product application.

Emulsifiers

Amphiphilic molecules that catalyze and stabilize the homogeneous blending and dispersing of one phase into another (e.g. oil into water). These are most commonly anionic or non-ionic in nature.

Viscosity enhancers

Typically waxes or polymers that build colloidal structures, networks or microstructures that increase the viscosity of emulsions thereby improving cream emulsion stability and also allowing the user to effectively transfer the product from the primary package to the location of application.

Solvents

Both lipophilic and hydrophilic fluids may be used to enhance the solubilization of APIs, prevent crystallization or stabilize crystal habits and polymorphs in topical semi-solid formulations.

Penetration enhancers

The delivery of APIs through the stratum corneum and into the skin can be accelerated by a variety of different materials. The choice of the right material is determined by the physico-chemical characteristics of the API (e.g. melting point, molecular weight, polarity, iconicity, etc.).

Discover more solutions about creme formulations

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Trends and Formulation Strategies for Topical Drugs

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Topical Dosage Forms: Addressing Challenges with Cremes

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Discover our wide portfolio of excipients for cream and emulsion formulation

Kollicream® 3C

A mild, emollient, solubilizer and skin penetration enhancer for dermal applications.

Kollicream® CP 15

A high viscosity, waxy emollient for dermal applications.

Kollicream® IPM

A fast spreading emollient with broad penetration enhancement properties for lipophilic APIs.

Kollicream® OA

A medium spreading emollient with penetration enhancement properties, and a potential solvent for lipophilic solvents.

Kollicream® OD

A medium spreading non-ester emollient which is stable against acid and base hydrolysis and provides good skin penetration.

Kolliphor® CS 12

A non-ionic emulsifier; stable with acidic, basic and ionic excipients.

Kolliphor® CS 20

A non-ionic emulsifier with good sensory properties; stable with acidic, basic and ionic excipients.

Kolliphor® CS A

An easy-to-use, self-bodying cream base.

Kolliphor® CS L

A self-emulsifying mixture of emulsifier and consistency factors for simplified preparation of skin cream base.

Kolliphor® CSS

An anionic emulsifier for topical pharmaceutical applications.

Kolliphor® P 338

A polymeric multi-talent suitable for a large variety of applications, i.e. Kolliphor® P 338 can be used as solubilizer, emulsifier and plasticizer.

Kolliwax® CA

A commonly used fatty alcohol, consistency factor.

Kolliwax® CSA 50

A fatty alcohol mixture, preferred for its stability in emulsion formulations.

Kolliwax® CSA 70

A fatty alcohol mixture, preferred for its stability in emulsion formulations.

Kolliwax® MA

An O/W co-emulsifier and consistency factor with low melting point and soft sensory effect.

Kolliwax® SA

As lipophilic lubricant Kolliwax® SA is the first choice for sensitive acidic APIs. It is commonly also used as viscosity regulator for oil-in-water emulsions and as a pH independent sustained release agent. Kolliwax® SA acts as a plasticizer with included consistency factor in solid dispersions. It hardens suppository formulations and adjust their melting points.

Novata®

The best option for suppository masses or solid compositions.

Kollidon® VA64

Kollidon® VA64 is used in granulation and as a dry binder in tablets, capsules and granules, as a film-forming agent in tablet coatings and subcoatings, and as a film-forming agent in topical sprays. Soluble copovidone widely used for instant release formulation and is suitable in hot-melt extrusion processes.

Kolliphor® ELP

Kolliphor® ELP is a non-ionic oil-in-water emulsifier and/or solubilizer for sensitive active ingredients

Kolliphor® HS 15

A potent nonionic solubilizer

Kolliphor® PS 20

Kolliphor® PS 20 is a non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer for pharmaceutical preparations like emulsions and creams, gels and foams as well as softgels.

Related Solution Platform

Skin Delivery Platform

The perfect solution for every skincare challenge.

Solubilization Platform

Effective solubilization in solid & liquid dosage forms.

Instant & Modified Release Platform

BASFs rich portfolio of instant and modified release solutions offers an unprecedented range of functionality.