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Excipients for Drug Formulation

 

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Global
Excipients for Drug Formulation

Pharmaceutical Foams

BASF offers wide range of excipients for topical formulations enabling you to create the ideal skin delivery solution for your foam formulation. 

By extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. Our range of solubilizers support effective delivery of the target API – the number-one priority when designing any dermatological product.

Topical foams are growing in importance in the topical dermatological field. These can take the form of aerosol foams with a dense, creamy consistency (e.g. mousse) or non-aerosol pump foams with a looser, less dense consistency. There are numerous advantages associated with foams: (1) They allow for the clean, targeted application of APIs that must be delivered from a liquid. (2) In aerosol systems all of the ingredients are typically completely solubilized in the primary package, thereby circumventing issues of physical stability that are associated with other dosage forms. (3) Foams can be a superior choice for vaginal or rectal applications.

Benefits

  • Extensive expertise and understanding of topical products
  • High quality consistency factors for improved stability and optimized sensory performance
  • Broad range of solubilizers for effective delivery of your target API
  • Meets the highest regulatory and quality requirements

Some of the key functional excipients that BASF offers for foam formulations include:

Emulsifiers

The air-water interface of foam cells (bubbles) is stabilized by emulsifiers. For aerosol foams any of our Kolliphor® series may be considered. For non-aerosol aqueous foams our Kolliphor® P series (poloxamers) are a superior choice.

Consistency factors

Fatty alcohols (e.g. Kolliwax® SA, Kolliwax® CA or Kolliwax® CSA 50) can be used to both increase the stability of foam lamellae (the thin film of liquid between bubbles) and optimize the sensory properties.

Solvents

Prior to extrusion as a foam APIs must be dissolved in the formulation. Our Kollisolv® and Kolliphor® products, as well as low molecular weight polyvinylpyrrolidones (Kollidon® 12 PF, Kollidon® 17 PF, Kollidon® 25 and Kollidon® 30) are all excellent options to consider as solubilizers.

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