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Excipients for Drug Formulation
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Excipients for Drug Formulation

Excipients for 
Suppositories

Global
Excipients for Drug Formulation

Suppositories

BASF offers a variety of matrix builders, solvents and emulsifiers suitable for suppositories.

Suppositories are an excellent dosage form for rectal and vaginal applications. Some of the advantages of suppositories include:

  • The API can be rapidly absorbed through colonic or vaginal mucosal membranes
  • The API is not exposed to digestive system or hepatic metabolism.

Important characteristics for suppositories include (1) hardness (for proper handling and delivery), (2) shape (for comfortable insertion and retention), (3) solubilization of drug in suppository matrix, and (4) rapid melting after application.

Suppositories can be formed from waxy matter, structured glycerine or poloxamer-based mixtures. The composition is tuned so that the suppository is solid at ambient temperature but rapidly melts at body temperature. Emulsifiers may be used to increase the solubility of the API in the suppository mass and also accelerate the dispersal of the API after the suppository melts.

Benefits

  • Broad range of matrix builders, solubilizers and emulsifiers for suppositories
  • Extensive expertise and understanding of topical products
  • Meets the highest regulatory and quality requirements

Functional excipients for suppositories include:

Solvents

Suppositories are composed of a balance of solid, higher melting point material combined with lower melting point fluids. The solvents may be hydrophilic (e.g. polyethylene glycols, propylene glycol, etc.) or hydrophobic (e.g. medium chain triglycerides, etc.)

Matrix builders

These excipients help forming the solid structure in suppositories, and which will melt at body temperature. In hydrophilic suppositories this may be poloxamers or higher melting point polyethylene glycols (i.e. Kollisolv® PEG 1450 or Kollisolv® PEG 8000). In hydrophobic suppositories this may be fatty acids or fatty alcohols and/or blends of these.

Emulsifiers

These excipients can aid in the dispersal of suppository solids and oils after the suppository melts and disassembles in the application site.

Learn more about our solutions for suppository formulations

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Discover our portfolio of functional excipients for suppositories

Kollicream® DO

A medium spreading emollient and solubilizer for lipophilic APIs.

Kollicream® IPM

A fast spreading emollient with broad penetration enhancement properties for lipophilic APIs.

Kollicream® OA

A medium spreading emollient with penetration enhancement properties, and a potential solvent for lipophilic solvents.

Kollicream® OD

A medium spreading non-ester emollient which is stable against acid and base hydrolysis and provides good skin penetration.

Kollidon® CL

The Kollidon® CL family is the industry’s widest portfolio of super-disintegrants and dissolution enhancers. These highly functional cross-linked PVP polymers ensure that active ingredients are released from any solid dosage form at exceptionally high speed. In addition, they improve bioavailability of certain poorly soluble APIs.

Kollidon® VA64

Kollidon® VA64 is used in granulation and as a dry binder in tablets, capsules and granules, as a film-forming agent in tablet coatings and subcoatings, and as a film-forming agent in topical sprays. Soluble copovidone widely used for instant release formulation and is suitable in hot-melt extrusion processes.

Kolliphor® CS L

A self-emulsifying mixture of emulsifier and consistency factors for simplified preparation of skin cream base.

Kolliphor® ELP

Kolliphor® ELP is a non-ionic oil-in-water emulsifier and/or solubilizer for sensitive active ingredients

Kolliphor® HS 15

A potent nonionic solubilizer

Kolliphor® P 338

A polymeric multi-talent suitable for a large variety of applications, i.e. Kolliphor® P 338 can be used as solubilizer, emulsifier and plasticizer.

Kolliphor® PS 20

Kolliphor® PS 20 is a non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer for pharmaceutical preparations like emulsions and creams, gels and foams as well as softgels.

Kolliphor® PS 60

Kolliphor® PS 60 is used as an emulsifier or co-emulsifier in topical pharmaceutical applications like creams and lotions and as non-ionic solubilizer in solid, semi-solid and liquid dosage forms or as foam stabilizer.

Kolliphor® PS 80

Kolliphor® PS 80 is a non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer for pharmaceutical preparations like like emulsions and creams, gels and foams as well as softgels.

Kollisolv® MCT 70

Medium chain triglyceride compatible with fat-soluble vitamins, actives and essential oils

Kollisolv® PEG 300

Excellent solvents for a large number of substances that do not readily dissolve in water

Kollisolv® PEG 400

Excellent solvents for a large number of substances that do not readily dissolve in water

Kollisolv® PEG 8000

A high molecular polyethylene glycol (macrogol) mainly used as solvent for oral, topical and parenteral preparations.

Kollisolv® PG

Manufactured under cGMP, Kollisolv® PG (1,2-propyleneglycol) can used across a wide range of applications, i.e. as plasticizer, solvent or co-solvent, stabilizer, or as carrier for emulsifiers.

Kolliwax® CA

A commonly used fatty alcohol, consistency factor.

Kolliwax® CSA 50

A fatty alcohol mixture, preferred for its stability in emulsion formulations.

Kolliwax® CSA 70

A fatty alcohol mixture, preferred for its stability in emulsion formulations.

Kolliwax® MA

An O/W co-emulsifier and consistency factor with low melting point and soft sensory effect.

Kolliwax® SA

As lipophilic lubricant Kolliwax® SA is the first choice for sensitive acidic APIs. It is commonly also used as viscosity regulator for oil-in-water emulsions and as a pH independent sustained release agent. Kolliwax® SA acts as a plasticizer with included consistency factor in solid dispersions. It hardens suppository formulations and adjust their melting points.

Kolliwax® S Fine

Kolliwax® S Fine can be used for various oral solid as well as semi-solid dosage forms: It can be used as a lubricant in oral dosage forms, matrix forming agent in sustained-release dosage forms, emulsifying and solubilizing agent in topical formulations and hardening agent in glycerin suppositories. Kolliwax® S Fine is particularly suitable for sensitive APIs.

Novata®

The best option for suppository masses or solid compositions.

Discover BASF's functional solutions for suppositories

Suppositories: Emulsifiers

BASF has a broad portfolio of compendial, GMP-manufactured emulsifiers suitable for use in suppository masses.

Suppositories: Matrix builders

BASF offers a variety of hard fats, waxy solids, PEGs and poloxamers ideal for use as matrix builder and structurants in suppository formulations.

Suppositories: Solubilizers and Solvents

BASF offers a variety of solubilizers and solvents ideal for suppository mass formulations.

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