Transdermal Patches

BASF offers a variety of polymeric matrix formers and solvents suitable for transdermal patch formulations.

Adhesive transdermal patches are a growing technology for API delivery. Transdermal patches (TDDS) can take a variety of forms (e.g. simple drug-in-adhesive, multilayered, reservoir, etc.). The key advantages of this dosage form are: (1) Frequency of patient dosing may be reduced, due to prolonged or controlled API delivery, (2) API can be delivered when oral application is not possible, (3) Patches can be designed to deliver drugs at a specific controlled rate, (4) Patch application is painless and with minimal aesthetic negatives, as compared to injections or poor tasting oral formulations, (5) patches are easily applied to patients who resist oral dosage forms (e.g. children, elderly, disabled, etc.).

Benefits

Variety of excipients suitable for API-solubilizing matrices in transdermal patches
Wide range of solubilizers and solvents used in transdermal patches
BASF offers polymers that are being explored for use in microneedle technologies.
Extensive expertise and understanding of topical products
Meets the highest regulatory and quality requirements

Functional excipients required for successful design of transdermal patches includes:

Polymeric matrix formers

In transdermal patches the API must remain solubilized in the adhesive or polymeric matrix that is placed against the skin surface. BASF has several excipients that are used to form API-solubilizing matrices in transdermal patches (e.g. Kollidon^® VA64, Soluplus^®, Kollidon^® CL, etc.)

Solvents

Low molecular weight polyvinylpyrrolidones (Kollidon^® 12 PF, Kollidon^®17 PF, Kollidon^® 25 and Kollidon^® 30), copovidone (Kollidon^® VA64), Triacetin (Kollisolv^® GTA), and others, can be used to prevent the recrystallization of APIs in TDDS patches. A variety of our emulsifiers (Kolliphor^®product range) can also be used as solubilizers of APIs in patches.

Microneedle Patches

Microneedle patches are also being explored for the delivery of large molecules across the stratum corneum barrier. The various forms of microneedles include coated solid microneedles, hollow solid microneedles and soluble microneedles. BASF has polymers that are being explored for use in microneedle technologies.

Discover more about our solutions for transdermal patches

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Discover our portfolio of functional excipients for transdermal patch formulations

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Kollicoat^® MAE 100 P

Enteric coating with release above pH 5.5, coming as partially pre-neutralized powder saving you the neutralization step.

Kollicream^® IPM

A fast spreading emollient with broad penetration enhancement properties for lipophilic APIs.

Kollicream^® OA

A medium spreading emollient with penetration enhancement properties, and a potential solvent for lipophilic solvents.

Kollicream^® OD

A medium spreading non-ester emollient which is stable against acid and base hydrolysis and provides good skin penetration.

Kollidon^® 12 PF

Low-molecular grade Kollidon^®, intended for use as solubilizing agent, dispersant and crystallization inhibitor particularly for injectables. In addition applicable as pore former in solid dosage forms and viscosity enhancer in parenterals.

Kollidon^® 17 PF

Low-molecular grade Kollidon^®, intended for use as solubilizing agent, dispersant and crystallization inhibitor, particularly for injectables. In addition applicable as pore former in solid dosage forms and viscosity enhancer in parenterals.

Kollidon^® 25

Our medium-molecular povidone is used in endless ways in pharmaceutical formulations - as binder, pore former, stabilizer, thickener, as solubilizing agent, crystallization inhibitor and many more. And with our trusted quality, it will always serve exactly what you intended it for.

Kollidon^® 30

Kollidon^® 30 LP

Our original, Kollidon^® 30 in a low peroxide version - protecting your oxygen-sensitive active ingredient longer.

Kollidon^® 90 F

A highly effective binder, for use as a stabilizer in oral and topical suspensions, as a thickener, and as a hydrophilizing agent or pore-forming agent in medical plastics.

Kollidon^® CL

The Kollidon^® CL family is the industry’s widest portfolio of super-disintegrants and dissolution enhancers. These highly functional cross-linked PVP polymers ensure that active ingredients are released from any solid dosage form at exceptionally high speed. In addition, they improve bioavailability of certain poorly soluble APIs.

Kollidon^® CL-M

Kollidon^® CL-M is used as a stabilizer for oral and topical suspensions and to improve the drug release characteristics of tablets, capsules or granules. Our disintegrant with micronized particles, delivers a slight disintegration functionality when used as binder. The crosspovidone is also used as pore former in some formulations.

Kollidon^® SR

Direct Compression Sustained Release

Kollidon^® VA64

Kollidon^® VA64 is used in granulation and as a dry binder in tablets, capsules and granules, as a film-forming agent in tablet coatings and subcoatings, and as a film-forming agent in topical sprays. Soluble copovidone widely used for instant release formulation and is suitable in hot-melt extrusion processes.

Kolliphor^® EL

BASF's non-ionic solubilizer and emulsifier for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds.

Kolliphor^® ELP

Kolliphor^® ELP is a non-ionic oil-in-water emulsifier and/or solubilizer for sensitive active ingredients

Kolliphor^® HS 15

A potent nonionic solubilizer

Kolliphor^® P188

Flexible excipient to overcome a wide range of pharmaceutical challenges that provide formulators with increased efficiency and added functionality.

Kolliphor^® PS 20

Kolliphor^® PS 20 is a non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer for pharmaceutical preparations like emulsions and creams, gels and foams as well as softgels.

Kollisolv^® GTA

A hydrophilic plasticizer used in both, aqueous and solvent-based polymeric coating of capsules, tablets and granules. Also used as a solubilizer and solvent as well as a humectant.

Kollisolv^® PG

Manufactured under cGMP, Kollisolv® PG (1,2-propyleneglycol) can used across a wide range of applications, i.e. as plasticizer, solvent or co-solvent, stabilizer, or as carrier for emulsifiers.

Kolliwax^® CA

A commonly used fatty alcohol, consistency factor.

Kolliwax^® MA

An O/W co-emulsifier and consistency factor with low melting point and soft sensory effect.

Novata^®

The best option for suppository masses or solid compositions.

Soluplus^®

With its excellent capability to form solid solutions, Soluplus^® is suitable for innovative processing technologies, such as hot melt extrusion. Soluplus^® was awarded with the CPhI Silver Innovation Award in 2010.