Transdermal Patches: Matrix Builders
BASF offers a selection of matrix builders for transdermal systems such as transdermal patches.
Transdermal patches can have a variety of different geometries and designs but the most basic types are drug-in-adhesive patches. These are composed of a thin layer of adhesive, containing dissolved drug, on a thin plastic or polymeric backing. The adhesives most frequently used are polyisobutylene, acrylate or silicone based. In some cases additional polymers may be required in order to be able to build a molecular architecture or matrix into which solvents and APIs may be stably formulated. In principle, any polymer that can be dissolved in a solvent, is miscible with the adhesive and can be cast into a coherent film, could fulfill this functionality. Kollidon® VA 64 is a very good candidate for consideration. Kollidon® CL-M (crospovidone), Kollidon® SR (coprocessed polyvinyl acetate (80%), povidone (19%), lauryl sulfate (0.8%) and silica (0.2%)), Kollicoat® MAE 100P (methacrylic acid-ethyl acrylate copolymer 1:1) and other polymers in the BASF Pharma Solutions coatings portfolio, may all be explored as matrix builders in transdermal systems.