Direct compression of solid oral dosage forms – a full range of functional solutions

The Kollidon^® CL family is the industry’s widest portfolio of super-disintegrants and dissolution enhancers. These highly functional cross-linked PVP polymers ensure that active ingredients are released from any solid dosage form at exceptionally high speed. In addition, they improve bioavailability of certain poorly soluble APIs.

Due to the balance of strong disintegration and optimal surface homogeneity our crosspovidone Kollidon^® CL-F is your first choice tablet disintegrant. The super-disintegrant is specifically suitable for use in small tablets to fasten disintegration and dissolution. Kollidon^® CL-F can also be used in wet granulation processes, when large amount of granulation liquids are needed.

Kollidon^® CL-M is used as a stabilizer for oral and topical suspensions and to improve the drug release characteristics of tablets, capsules or granules. Our disintegrant with micronized particles, delivers a slight disintegration functionality when used as binder. The crosspovidone is also used as pore former in some formulations.

The finest grade of water-insoluble crospovidone disintegrant available in the market for small and orally disintegrating tablets. It provides smooth tablet surface and cream-like mouth feel. Kollidon^® CL-SF strongly improves tablet hardness and has a strong ability to absorb water.

Direct Compression Sustained Release

Kollidon^® VA64 is used in granulation and as a dry binder in tablets, capsules and granules, as a film-forming agent in tablet coatings and subcoatings, and as a film-forming agent in topical sprays. Soluble copovidone widely used for instant release formulation and is suitable in hot-melt extrusion processes.

Highly effective soluble copovidone for dry binding due to a finer particle size and specifically designed for roller compaction and dry binding in Direct Compression formulations.

A water-soluble excipient supporting a variety of instant and modified release applications.

Kolliphor^® P 407 mico offers effective solubilization and perfect content uniformity in blends used in melt-granulation, hot-melt extrusion or for making tablets.

A widely used ionic solubilizer and high HLB anionic emulsifier that is suitable for application in liquid dispersions, solutions, emulsions and micro-emulsions to formulate tablets, foams and semi-solids such as creams, lotions and gels.

Kolliwax® HCO is hydrogenated castor powder for pharmaceutical application used as consistency factor in topical formulations, as lipohphillic lubricant in tablets and capsules and as plasticizer in solid dispersions using spray drying, melt granulation or hot melt extrusion processes. Kolliwax® HCO is particularily suitable for formulation of sensitive APIs.

As lipophilic lubricant Kolliwax^® SA is the first choice for sensitive acidic APIs. It is commonly also used as viscosity regulator for oil-in-water emulsions and as a pH independent sustained release agent. Kolliwax^® SA acts as a plasticizer with included consistency factor in solid dispersions. It hardens suppository formulations and adjust their melting points.

As lipophilic lubricant Kolliwax^® SA Fine is the first choice for sensitive acidic APIs. It is used as lubricant and matrix former. It hardens suppository formulations and adjust their melting points.

Kolliwax^® S Fine can be used for various oral solid as well as semi-solid dosage forms: It can be used as a lubricant in oral dosage forms, matrix forming agent in sustained-release dosage forms, emulsifying and solubilizing agent in topical formulations and hardening agent in glycerin suppositories. Kolliwax^® S Fine is particularly suitable for sensitive APIs.

Ludiflash^® is an all-in-one solution: filler, binder, and disintegrant that provides tablets with exceptional hardness and low friabilit, while giving your ODT an outstandingly creamy mouthfeel. It lowers storage and analytical costs and accelerates product development and process validation. Tableting is possible with any conventional equipment and any preferred packaging type. Ludiflash^® enhances the cohesion with API‘s and is compatible with many typical ingredients in standard formulations.

Ludipress^® – a granulate that means quicker, easier, and more cost-effective tableting. With Ludipress^®, you save precious time on developing, analyzing and blending. You simply add your active ingredient, a lubricant, and compress your tablets. It is that easy.

A ready-to-use direct compression solution for lozenges, chewables and effervescent tablet.

BASF offers disintegrants across a broad range of particle sizes, making any type of desired formulation possible.

BASF offers a comprehensive range of lubricants, particularly for sensitive active ingredients.

BASF offer specific highly functional matrix formers as well as a selection of ready-to-use tablet and ODT bases that include filler and all other necessary components.