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Excipients for Drug Formulation

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for physical mixing

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Global
Excipients for Drug Formulation

Physical Mixing

BASF offers a broad portfolio of functional excipients suitable for physical mixing processes.

Did you know that the role of excipients play a more relevant role to the bioavailability enhancement of a drug molecule than the process technology? Discussing drug delivery systems such as amorphous solid dispersions it is often overseen that the excipient can enhance the drug’s bioavailability often sufficiently already when not being processed by so-called enabling technologies such as hot melt extrusion or spray drying. BASF spend a significant resources in the investigation of standard processes you have in-house available such as standard dry granulation, wet granulation and melt granulation for the enhancement of a drug’s bioavailability. BASF could proof that using functional excipients such as Soluplus® in a wet granulation process could enhance the dissolution of Danazol to 80% performance compared to a corresponding melt extruded solid dispersion.

By this BASF reached a milestone as such formulation reach a sufficient bioavailability enhancement at a much better risk profile. As the drug can remain in its crystalline state, there is no risk of re-crystallisation in solid state. Furthermore there is no risk of changing dissolution profiles due to relaxation issues as they are known from amorphous solid dispersionsTalk to us about how BASF can help you enhancing your drug’s bioavailability at a lowest possible formulation risk profile.

Benefits

  • Broad portfolio of functional excipients suitable for physical mixing processes
  • Deep expertise in bioavailability and solubility enhancement of drugs
  • Pioneer in hot melt extrusion processes

Instant & Modified Release

BASFs rich portfolio of instant and modified release solutions offers an unique range of functionality.

Solubilization

Effective solubilization in solid & liquid dosage forms.

Wet Granulation

BASF offers the key functional materials required to achieve great wet granulation results.

Hot Melt Extrusion

Bioavailability enhancement using hot melt extrusion.

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Discover our excipient product range suitable for physical mixing processes