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Excipients for Drug Formulation

Kollicoat® MAE 100-55

A complete match – just better. Kollicoat® MAE 100-55 combines two things hard to bring together – it can directly exchange the comparable pH 5.5 enteric release coating polymer in your commercial formulations, and still bring significant handling improvement to your operators because it does not dust at all.

Kollicoat® MAE 100-55 is the latest addition to our comprehensive portfolio of functional excipients in our Instant & Modified Release Platform. It extends our offer of pH >5.5 enteric release products based on methacrylic acid-ethylacrylate copolymer, providing you even more flexibility.

Why choose Kollicoat® MAE 100-55

  • Direct substitution in commercial enteric release formulations based on methacrylic acid-ethylacrylate copolymer with an opening pH > 5.5
  • Easier handling due to dust-free material
  • Compliant with respective monographs

Kollicoat® MAE 100-55
(non-neutralized powder)

  • Allows direct substitution incommercial formulations
  • Aqueous & organic coating

Kollicoat® MAE 100 P 
(pre-neutralized powder)

  • No neutralization required
  • Suitable for extreme weather (powder)
  • Aqueous coating

Kollicoat® MAE 30 DP
(dispersion 30%)

  • Most efficient and cost-effective (not spray-dried)
  • Aqueous coating
  • Not suitable for freezing climate

No more dusting thanks to unique powder particle shape

The dry powder particles of Kollicoat® MAE 100-55 are larger and thus significantly less dusty than comparable 100-55 coating grades – much easier to work with for your operators:

Equivalent drug release

Despite its advantages in handling, Kollicoat® MAE 100-55 provides equivalent drug release as existing comparable coating grades in the market. And this means you can directly introduce it into your commercialized formulations.

Coated Bupropion HCl tablets (150mg);
N = 3; 50 rpm;
Buffer change after 2 h;
880ml HCl + 20 ml Tri-K phosphate

Quality and regulatory status

Kollicoat® MAE 100-55 is produced in Germany under GMP conditions. It complies to respective Ph.Eur., USP-NF, and JPE monographs:

Product Details
Ph.Eur. Methacrylic Acid – Ethyl Acrylate Copolymer (1:1) Type A
USP/NF Methacrylic Acid and Ethyl Acrylate Copolymer NF (revision Dec 1st, 2015)
JPE Dried Methacrylic Acid Copolymer LD

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