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Excipients for Drug Formulation

Kollicoat® MAE 100 P

Reliable and safe enteric coating

Kollicoat® 100 P is a reliable, high-performance film coating based on methacrylic aid-ethyl acrylate copolymer (1:1), designed specifically for enteric tablet coating. Many APIs degrade in the acidic environment of the stomach or irritate its lining. But the smart polymers in Kollicoat® MAE shield active ingredients from aggressive gastric juice and only dissolve once in the intestine – making sure the API is released in precisely the right place. Kollicoat® MAE 100 P is a partially neutralized powder for rapid re-dispersion. Both grades offer robust protection, while facilitating more simple and cost-effective production processes.

Why choose Kollicoat® MAE?

  • Reliable, high-performance enteric film coating
  • Excellent resistance to gastric juices
  • Rapid release at pH values greater than 5.5
  • Easyand efficient processing

Application examples

Protection of gastro-sensitive active
ingredients

 

Protection of gastric mucosa from aggressive actives

 

Gastrointestinal targeting

e.g. proton-pump inhibitors, enzymes, peptides, antibiotics

e.g. COX-1-inhibitors, iron compounds, acetylsalicylic acid, diclofenac-sodium

e.g. budesonide, clarithromycin, doxazosin, pancreatic enzymes

Product Details
Applications: The main application is as film-former in enteric coatings for solid dosage forms.
Chemical name: Methacrylic acid ethyl acrylate copolymer
Trivial Names: Methacrylic Acid Copolymer Type C (USP), Methacrylic Acid Copolymer LD (JPE) and Methacrylic Acid-Ethyl Acrylate Copolymer (Ph. Eur.), Methacrylsäure Copolymer. 
Description: The Kollicoat® MAE grades contain 0.7% sodium lauryl sulfate and 2.3% Polysorbate 80 as emulsifying agents. (The percentages refer to the solid substances.) The fatty acids used in the manufacture of Polysorbate 80 are of vegetable origin. The Kollicoat MAE grades are weakly acidic copolymers that dissolve at a pH above 5.5. 
Product Form: Kollicoat® MAE 100 P is a white redispersible powder with a faint characteristic odour. The neutralized carboxyl groups in the powder make it easy to redisperse in water without further auxiliaries. The properties and processing requirements of latices produced with it are the same as those of Kollicoat® MAE 30 DP, from which it is manufactured. 
CAS-No: 25212-88-8
INCI: Acrylates Copolymer
Regulatory Status: Kollicoat® MAE 100 P meets the requirements of the current monograph for Methacrylic Acid - Ethylacrylate Copolymer 1:1 (Type B) in Ph. Eur.
Registrations Kollicoat® MAE 100 P:
  • Ph. Eur – Methacrylic acid – ethyl acrylate copolymer (1:1) type B
  • USP/NF – Partially neutralized methacrylic acid and ethyl acrylate copolymer

Discover more about Kollicoat® MAE 100 P 

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