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Excipients for Drug Formulation
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Excipients for Drug Formulation
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Excipients for Drug Formulation

Kollicoat® Protect

Effective and reliable moisture protection for your active ingredients

Kollicoat® Protect is a combination of water-soluble Kollicoat® IR and polyvinyl alcohol. This instant release coating is highly impermeable to water – making it ideal for moisture-sensitive active ingredients and greatly increasing formulation stability. What’s more, processing is fast and straightforward: this highly flexible film former can be prepared at room temperature, and no plasticizer is required. Thanks to the polymer’s low viscosity, it is possible to create spray suspensions with a solids content of 20 percent – for exceptionally cost-efficient manufacturing processes.

Why choose Kollicoat® Protect?

  • Water-soluble polymer combination for moisture protection
  • Simple formulation, no plasticizer required
  • Robust production processes for consistently good results Smooth scale-up of operations
Product Details
Chemical nature: Owing to the special spray-drying process for Kollicoat® Protect, the polymers are embedded in one another to such an extent that they cannot separate. The powder has good flowability and dissolves rapidly in water.
Chemical name:  Polyvinyl alcohol-polyethylene glycol copolymer and polyvinyl alcohol (PVA)
CAS-No:
  • Kollicoat® IR 96734-39-3
  • Polyvinyl alcohol 9002-89-5
  • Silicon dioxide 7631-86-9
Regulatory Status:
  • Kollicoat® IR (film forming polymer in Kollicoat Protect) has been globally approved in medicinal products in all relevant regions, including Europe, Japan and the US.
  •  A Ph. Eur. monograph with the title "Macrogol Poly(vinylalcohol) Grafted Copolymer is included in Ph. Eur. 6.7.
  • A draft USP/NF monograph entitled "Ethylene Glycol and Vinyl Alcohol Graft Copolymer" is published in Pharmacopeial Forum 35(2). The new NF monograph will be included in USP 33, Supplement 1.
Applications:  Together with pigments Kollicoat® Protect gives an excellent moisture protection and taste masking effect. Further to this it can be used as a peroxide-free wet granulation binder or as a pore former in sustained release coatings.

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Related Functionalities

Film Forming

In formulation processes film formers provide a range of functionalities via a coating layer. BASF offers a full range of highly efficient film formers for all dosage forms.

Moisture Protection

BASF offers moisture protective coatings that active ingredients remain unaffected from environmental moisture across its lifetime.

Softgel Coatings

Customized solutions for the effective coatings of softgels to provide enteric sustained release and moisture protection.

Instant Release

An instant release profile enables the immediate beginning of the dissolving process of a dosage form once it has been swallowed and reached the patient’s stomach. BASF offers highly functional, instant release polymers.

Polymers for the shell

Easy to process coating solutions for enteric and sustained release and moisture protection

Related Process Technologies

Coating / Layering

Solid oral dosage forms are coated to apply a range of functions: from attractive colored instant-release coatings or robust taste-masking to functional coatings defining enteric or sustained release. BASF offers all major coating types plus as well as plasticizers for your successful coating formulation.

Hot Melt Extrusion

Hot-melt extrusion has been used in the plastics & food industries for decades. In the 1980s, BASF became the first company to apply it to the production of pharmaceuticals for enhancing the solubility and bioavailability of poorly soluble actives. Today, HME is an accepted process for creating solid dispersions of APIs.

Melt Granulation

Melt granulation is a great process option in a formulators' biovailability enhancement arsenal. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation.

Spray Drying

Spray drying is an established technology in the pharmaceutical industry to create amorphous, soluble forms of active ingredients. Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. BASF offers a wide range of functional polymers to choose from, along with all other excipients typically used in the formulation.

Related Special Applications

Solid Dispersions

In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility & bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

Related Solution Platforms

Instant & Modified Release Platform

BASFs rich portfolio of instant and modified release solutions offers an unprecedented range of functionality.

Softgel Coatings

Customized solutions for the effective coatings of softgels to provide enteric sustained release and moisture protection.

Softgels Platform

Functional solutions for all soft gel parts – fill, shell and coating.

Softgels: Capsule Shell

Comprehensive portfolio of easy to process solutions for enteric and sustained release and moisture protection

Solubilization Platform

Effective solubilization in solid & liquid dosage forms.