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Excipients for Drug Formulation

Kollicoat® Smartseal 30 D

Breaking new ground in taste masking and moisture protection

Kollicoat® Smartseal 30 D is the first water based polymer dispersion for taste masking and moisture barrier applications. It was developed to simplify and accelerate aqueous film coating operations and opens new doors for formulating tablet, pellet and particle coatings.

    

The best of both worlds

Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators - but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier, can be achieved with one functional film-forming polymer.

Kollicoat® Smartseal 30 D is highly impermeable to water vapor, helping preserve the potency of sensitive active ingredients. What’s more, the polymer is highly stable in saliva and specifically soluble in gastric juice. This ensures effective protection from unpleasant tastes in the patient’s mouth and rapid release and onset of action of active ingredients in the stomach.

As an aqueous polymer dispersion, Kollicoat® Smartseal 30 D is easy to handle, and convenient to apply. And since it can be used in highly concentrated coating suspensions and at high spray rates, you benefit from reduced process times – and significant cost savings.

Why choose Kollicoat® Smartseal 30 D?

  • Smart protection from unpleasant taste
  • Effective sealing against moisture
  • Fast release of active ingredients
  • Easy and economical film coating

Applications

Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators- but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier can be achieved Kollicoat® Smartseal 30 D.

Moisture protection

Some active ingredients and certain dosage forms (matrix tablets or formulations with a disintegrant) must be protected from moisture. A protective film coating can help preserve the potency of sensitive active ingredients. This is particularly important during packaging or after dispensing the product.

Strong sealing against moisture
Film coatings with a low water vapor permeability can delay the moisture uptake of sensitive cores. Tests on isolated films show that Kollicoat® Smartseal 30 D has a lower water vapor permeability than other leading protective coatings.

Taste masking

The formulation of orally disintegrating tablets (ODTs) or other applications which are easier to dose and more convenient to apply (such as sprinkles) can help to improve patient compliance. Taste masking of pellets or particles is particularly important - and challenging – in the development of such dosage forms.

Smart protection from unpleasant taste
Due to the extraordinary stability in the saliva and the specific solubility in gastric juice, Kollicoat® Smartseal 30 D ensures effective protection from unpleasant tastes in the patients mouth and rapid release and onset of action of the active ingredients in the stomach. Kollicoat® Smartseal 30 D hides bitter taste with a significantly reduced coating thickness. For example, it masks the taste of quinine hydrrochloride tablets more effectively than other leading protective coatings. 

Easy and economical film coating

An aqeous dispersion, Kollicoat® Smartseal 30 D is easy to handle and convenient to apply. The low viscosity of Kollicoat® Smartseal 30 D allows the preparation of highly concentrated coating suspensions. And since it can also be used at high spray rates, you benefit from reduced coating times and significant cost savings.

Kollicoat® Smartseal 30 D – Active Protection

Breaking new ground in taste masking and moisture protection: Kollicoat Smartseal® 30 D is the first waterbased polymer dispersion for taste masking and moisture barrier applications. It was developed to simplify and accelerate aqueous film coating operations, and opens new doors for formulating tablet, pellet, particle and softgel coatings.

Product

Kollicoat® Smartseal 30 D is an aqueous dispersion of a co-polymer comprising methyl methacrylate (MMA) and diethylaminoethyl methacrylate (DEAEMA) in a ratio of 6:4. It also contains macrogol cetostearylether 20 (~0.6%) and sodium laruyl sulfate (~0.8%) as stabilizers and has a solids content of 30%.

An aqueous polymer dispersion, Kollicoat® Smartseal 30 D is easy to handle and convenient to apply. And since it can be used in highly concentrated coating suspensions and at high spray rates, you benefit from reduced process times - and significant cost savings.

Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators - but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier can be achieved Kollicoat® Smartseal 30 D.

Kollicoat® Smartseal 30 D is highly impermeable to water vapor, helping preserve the potency of active ingredients. What's more, the polymer is highly stable in saliva and specifically soluble in gastric juice.

Product Details
Chemical structure: Kollicoat® Smartseal 30 D is an aqueous dispersion of a co-polymer comprising methyl methacrylate (MMA) and diethyla- minoethyl methacrylate (DEAEMA). It also contains macrogol cetostearylether and sodium lauryl sulfate as stabilizers.
Trivial names: Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion
PRD-No: 30492630 (BASF’s commercial product number)
Description: Kollicoat® Smartseal 30 D is an aqueaous polymer dispersion with a solids con- centration of approx. 30%. It contains methyl methacrylate and diethylaminoethyl methacrylate copolymer stabilized with approx. 0.6% macrogol cetostearyl ether and 0.8% sodium lauryl sulfate. It comes as a milky white to yellowish liquid with a faint characteristic odor.
Regulatory status: Type IV US-DMF and type V US DMF are available.
Molecular weight: The weight average molecular weight determined with size exclusion chromatography (SEC) – light scattering is approx. 200 000 dalton.
Solubility:

Kollicoat® Smartseal 30 D is miscible with water while retaining its milky white appearance and low viscosity. When hydrophilic organic solvents are added, the polymer precipitates at first, but dissolves after continuous stirring:

  • Acetone: Miscible at a ratio of 1:3, dissolves after 2 hrs (solution is cloudy)
  • Ethanol: Miscible at a ratio of 1:3, dissolves after 2.5 hrs (solution has a yellowish color)
  • Isopropanol: Miscible at a ratio of 1:3, dissolves after 3.5 hrs (solution has a yellowish color)

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