Kollicoat® Smartseal 30 D
Breaking new ground in taste masking and moisture protection
Kollicoat® Smartseal 30 D is the first water based polymer dispersion for taste masking and moisture barrier applications. It was developed to simplify and accelerate aqueous film coating operations and opens new doors for formulating tablet, pellet and particle coatings.
Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators - but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier, can be achieved with one functional film-forming polymer.
Kollicoat® Smartseal 30 D is highly impermeable to water vapor, helping preserve the potency of sensitive active ingredients. What’s more, the polymer is highly stable in saliva and specifically soluble in gastric juice. This ensures effective protection from unpleasant tastes in the patient’s mouth and rapid release and onset of action of active ingredients in the stomach.
As an aqueous polymer dispersion, Kollicoat® Smartseal 30 D is easy to handle, and convenient to apply. And since it can be used in highly concentrated coating suspensions and at high spray rates, you benefit from reduced process times – and significant cost savings.
Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators- but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier can be achieved Kollicoat® Smartseal 30 D.
Kollicoat® Smartseal 30 D is an aqueous dispersion of a co-polymer comprising methyl methacrylate (MMA) and diethylaminoethyl methacrylate (DEAEMA) in a ratio of 6:4. It also contains macrogol cetostearylether 20 (~0.6%) and sodium laruyl sulfate (~0.8%) as stabilizers and has a solids content of 30%.
An aqueous polymer dispersion, Kollicoat® Smartseal 30 D is easy to handle and convenient to apply. And since it can be used in highly concentrated coating suspensions and at high spray rates, you benefit from reduced process times - and significant cost savings.
Bitter and moisture-sensitive active ingredients can pose quite a challenge to formulators - but not anymore. Either of the two desired effects, concealing unpleasant tastes and creating a moisture barrier can be achieved Kollicoat® Smartseal 30 D.
Kollicoat® Smartseal 30 D is highly impermeable to water vapor, helping preserve the potency of active ingredients. What's more, the polymer is highly stable in saliva and specifically soluble in gastric juice.
Product Details | |
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Chemical structure: | Kollicoat® Smartseal 30 D is an aqueous dispersion of a co-polymer comprising methyl methacrylate (MMA) and diethyla- minoethyl methacrylate (DEAEMA). It also contains macrogol cetostearylether and sodium lauryl sulfate as stabilizers. |
Trivial names: | Methyl methacrylate and diethylaminoethyl methacrylate copolymer dispersion |
PRD-No: | 30492630 (BASF’s commercial product number) |
Description: | Kollicoat® Smartseal 30 D is an aqueaous polymer dispersion with a solids con- centration of approx. 30%. It contains methyl methacrylate and diethylaminoethyl methacrylate copolymer stabilized with approx. 0.6% macrogol cetostearyl ether and 0.8% sodium lauryl sulfate. It comes as a milky white to yellowish liquid with a faint characteristic odor. |
Regulatory status: | Type IV US-DMF and type V US DMF are available. |
Molecular weight: | The weight average molecular weight determined with size exclusion chromatography (SEC) – light scattering is approx. 200 000 dalton. |
Solubility: | Kollicoat® Smartseal 30 D is miscible with water while retaining its milky white appearance and low viscosity. When hydrophilic organic solvents are added, the polymer precipitates at first, but dissolves after continuous stirring:
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