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Excipients for Drug Formulation
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Excipients for Drug Formulation
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Excipients for Drug Formulation

Kollidon® CL

The Kollidon® CL family is the industry’s widest portfolio of super-disintegrants and dissolution enhancers. These highly functional cross-linked PVP polymers ensure that active ingredients are released from any solid dosage form at exceptionally high speed. In addition, they improve bioavailability of certain poorly soluble APIs. 

The insoluble grades of Kollidon® (Crospovidone) are manufactured by a polymerization process that yields crosslinked insoluble polyvinylpyrrolidone in the form of a “popcorn” polymer. The polymerisation is performed using an aqueous system. Neither organic solvents nor radical starters are involved at any stage. Kollidon® CL is available as standard, fine, superfine and micronized grade.

Kollidon® CL - Your benefits

  • The industry’s widest portfolio of super-disintegrants and dissolution enhancers
  • Improved release characteristics of tablets, capsules and granules
  • Exceptionally fast release of active ingredients in solid dosage forms
  • Consistently high quality for reliable performance and formulation stability
  • The original PVP from the industry’s most experienced team

The insoluble Kollidon® CL-grades possess a number of useful properties for pharmaceutical products.

  • Improvement of tablet disintegration through predictable swelling without gel-formation
  • Swelling properties paired with particle size distribution make the fine Kollidon® CL-grades work efficiently in fast disintegrating formulations
  • In contrast to other disintegrants the Kollidon® grades improve the release and the bioavailability of drugs through complex formation
  • Kollidon® grades feature selective adsorption of polyphenols by complex formation
  • Kollidon® grades feature selective complex formation with some endotoxins
Product Details
Chemical name: Polyvinylpyrrolidone, crosslinked
Synonyms: Crospovidone, crospovidonum, insoluble polyvinylpyrrolidone, crosslinked PVP. 
CAS-No: 9003-39-08
INCI: PVP
Regulatory Status: Kollidon® CL meets the requirements of the current monographs for crospovidone in Ph. Eur., USP/NF and JPE. Due to its particle size Kollidon® CL corresponds to Type A in Ph. Eur.
Description: The insoluble Kollidon® grades are supplied as fine white or almost white powders. They have a slight characteristic odor and are practically tasteless. They are insoluble in all of the usual solvents.
Applications: The main function is as super-disintegrant in tablets to fasten disintegration and dissolution. Like the soluble products crospovidone improves the bioavailability of some hardly soluble actives.

Learn more about Kollidon® CL

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Melt Granulation

Melt granulation is a great process option in a formulators' biovailability enhancement arsenal. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation.

Direct Compression

Direct compression (DC) is the most economic way to produce a tablet as it is the shortest and most direct way to get from powder mix to final dosage form. BASF offers all functional excipients to successfully develop a DC process for your drug, including key elements like appropriate binder and lubricant.

Hot Melt Extrusion

Hot-melt extrusion has been used in the plastics & food industries for decades. In the 1980s, BASF became the first company to apply it to the production of pharmaceuticals for enhancing the solubility and bioavailability of poorly soluble actives. Today, HME is an accepted process for creating solid dispersions of APIs.

Spray Drying

Spray drying is an established technology in the pharmaceutical industry to create amorphous, soluble forms of active ingredients. Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. BASF offers a wide range of functional polymers to choose from, along with all other excipients typically used in the formulation.

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BASF offers the key functional materials required to achieve great wet granulation results.

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