The Kollidon® CL family is the industry’s widest portfolio of super-disintegrants and dissolution enhancers. These highly functional cross-linked PVP polymers ensure that active ingredients are released from any solid dosage form at exceptionally high speed. In addition, they improve bioavailability of certain poorly soluble APIs.
The insoluble grades of Kollidon® (Crospovidone) are manufactured by a polymerization process that yields crosslinked insoluble polyvinylpyrrolidone in the form of a “popcorn” polymer. The polymerisation is performed using an aqueous system. Neither organic solvents nor radical starters are involved at any stage. Kollidon® CL is available as standard, fine, superfine and micronized grade.
|Chemical name:||Polyvinylpyrrolidone, crosslinked|
|Synonyms:||Crospovidone, crospovidonum, insoluble polyvinylpyrrolidone, crosslinked PVP.|
|Regulatory Status:||Kollidon® CL meets the requirements of the current monographs for crospovidone in Ph. Eur., USP/NF and JPE. Due to its particle size Kollidon® CL corresponds to Type A in Ph. Eur.|
|Description:||The insoluble Kollidon® grades are supplied as fine white or almost white powders. They have a slight characteristic odor and are practically tasteless. They are insoluble in all of the usual solvents.|
|Applications:||The main function is as super-disintegrant in tablets to fasten disintegration and dissolution. Like the soluble products crospovidone improves the bioavailability of some hardly soluble actives.|
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