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Excipients for Drug Formulation

Kollidon® SR

The matrix former providing superior sustained release

Kollidon® SR is a polyvinyl acetate and povidone based matrix retarding agent. It is particularly suitable for manufacturing of pH-independent sustained-release matrix tablets by direct compression or hot melt extrusion. Polyvinyl acetate is a very plastic material that produces a coherent matrix even under low compression forces. When the tablets are introduced into gastric or intestinal fluid, the water soluble povidone is leached out to form pores through which the active ingredient slowly diffuses outwards. Kollidon® SR contains no ionic groups and is therefore inert to drug substances. The sustained-release properties are unaffected by ions or salts.

Why choose Kollidon® SR?

  • Polyvinyl acetate and povidone based matrix for sustained release
  • Excellent flowability and tabletability
  • Suitable for direct compression
  • Low hygroscopicity
Product Details
Chemical name: Polyvinyl acetate/polyvinylpyrrolidone
Monography name/Chemical name: 80% PVAc, 19% Povidone, 0.8% SLS, 0.2% Silica 
CAS-No: 9003-20-7 + 9003-39-8
Regulatory Status: As Kollidon® SR is a blend no monograph exists. A US-DMF is filed. The methods for the analytical characterisations are taken from the Ph. Eur.
Applications: The main application is for the production of pH-independent sustained-release matrix tablets by direct compression.
Description: White or slightly yellowish, free-flowing powder. 

Solublity:

  • Insoluble in water (The povidone part is soluble but the polyvinyl acetate part is insoluble).
  • It is very soluble in N-methylpyrrolidone.

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