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Excipients for Drug Formulation

Kollidon® SR

The matrix former providing superior sustained release

Kollidon® SR is a polyvinyl acetate and povidone based matrix retarding agent. It is particularly suitable for manufacturing of pH-independent sustained-release matrix tablets by direct compression or hot melt extrusion. Polyvinyl acetate is a very plastic material that produces a coherent matrix even under low compression forces. When the tablets are introduced into gastric or intestinal fluid, the water soluble povidone is leached out to form pores through which the active ingredient slowly diffuses outwards. Kollidon® SR contains no ionic groups and is therefore inert to drug substances. The sustained-release properties are unaffected by ions or salts.

Why choose Kollidon® SR?

  • Polyvinyl acetate and povidone based matrix for sustained release
  • Excellent flowability and tabletability
  • Suitable for direct compression
  • Low hygroscopicity
Product Details
Chemical name: Polyvinyl acetate/polyvinylpyrrolidone
Monography name/Chemical name: 80% PVAc, 19% Povidone, 0.8% SLS, 0.2% Silica 
CAS-No: 9003-20-7 + 9003-39-8
Regulatory Status: As Kollidon® SR is a blend no monograph exists. A US-DMF is filed. The methods for the analytical characterisations are taken from the Ph. Eur.
Applications: The main application is for the production of pH-independent sustained-release matrix tablets by direct compression.
Description: White or slightly yellowish, free-flowing powder. 

Solublity:
  • Insoluble in water (The povidone part is soluble but the polyvinyl acetate part is insoluble).
  • It is very soluble in N-methylpyrrolidone.

Discover more about Kollidon® SR

Website

PVP (Polyvinyl pyrrolidone) – An all-round talent with tradition

Learning Tool

Overcoming Challenges in Sustained-Release Drug Formulation

ebook

Overcoming Challenges in Sustained-Release Drug Formulation

American Pharmaceutical Review

Controlled Release: A New Paradigm with Polyvinyl Acetate Polymer

Portfolio Overview

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Download Center

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Related Functionalities

Sustained Release

Sustained release profiles allow tailored dosing of the active ingredient over an extended period of time up to 24 hours. Common ways to achieve such release rates are the use of film coating, a sustained release matrix or sustained release drug-loaded granules. BASF offers powerful excipients that provide almost endless design space for sustained release formulations.

Matrices & Fillers

BASF offer specific highly functional matrix formers as well as a selection of ready-to-use tablet and ODT bases that include filler and all other necessary components.

Film Forming

In formulation processes film formers provide a range of functionalities via a coating layer. BASF offers a full range of highly efficient film formers for all dosage forms.

Coating / Layering

Solid oral dosage forms are coated to apply a range of functions: from attractive colored instant-release coatings or robust taste-masking to functional coatings defining enteric or sustained release. BASF offers all major coating types plus as well as plasticizers for your successful coating formulation.

Transdermal Patches: Matrix builders

BASF offers a selection of matrix builders for transdermal systems (i.e. transdermal patches).

Film forming

BASF has a robust portfolio of polymeric film formers to meet a variety of needs.

Solid Dispersions

In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility & bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

Related Process Technologies

Melt Granulation

Melt granulation is a great process option in a formulators' biovailability enhancement arsenal. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation.

Direct Compression

Direct compression (DC) is the most economic way to produce a tablet as it is the shortest and most direct way to get from powder mix to final dosage form. BASF offers all functional excipients to successfully develop a DC process for your drug, including key elements like appropriate binder and lubricant.

Hot Melt Extrusion

Hot-melt extrusion has been used in the plastics & food industries for decades. In the 1980s, BASF became the first company to apply it to the production of pharmaceuticals for enhancing the solubility and bioavailability of poorly soluble actives. Today, HME is an accepted process for creating solid dispersions of APIs.

Spray Drying

Spray drying is an established technology in the pharmaceutical industry to create amorphous, soluble forms of active ingredients. Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. BASF offers a wide range of functional polymers to choose from, along with all other excipients typically used in the formulation.

Wet Granulation

BASF offers the key functional materials required to achieve great wet granulation results.

Related Special Applications

Solid Dispersions

In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility & bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

Topical Polymeric Films

BASF offers a number of film formers and plasticizers for topical formulations enabling you to create the ideal skin delivery solution for your topical polymeric film formulation.

Transdermal Patches

BASF offers a variety of polymeric matrix formers and solvents suitable for transdermal patch formulations.

Related Solution Platforms

Instant & Modified Release Platform

BASFs rich portfolio of instant and modified release solutions offers an unprecedented range of functionality.

Skin Delivery Platform

The perfect solution for every skincare challenge.

Solubilization Platform

Effective solubilization in solid & liquid dosage forms.