Excipients for Drug Formulation

Kollidon® VA64 Fine

Highly effective soluble copovidone for dry binding due to a finer particle size and specifically designed for roller compaction and dry binding in Direct Compression formulations.

Kollidon® VA 64 Fine is a vinylpyrrolidone-vinyl acetate copolymers. It is used as dry binder in tablets, as granulating agents, as retarding and as a film-forming agents. Kollidon® VA 64 Fine is especially suitable for markets with high humidity exposure. Kollidon(R) VA 64 can be applied in direct compression processes such as roller compaction, hot melt extrusion processes and for controlled release preparations. 

SEM pictures of Kollidon® VA 64 Fine show a typical spray-dried powder with hollow spheres

Benefits of Kollidon® VA 64 Fine

  • The original PVP from the industry’s most experienced team
  • Especially suitable for direct compression, roller compaction, hot melt extrusion processes as well as for markets with high humidity exposure
  • Superior plasticity for very hard tablet production
  • Compliant with the current monographs for copovidone.
  • Consistently high quality for reliable performance and formulation stability

Applications of Kollidon® VA64 Fine

Product Details
Chemical name: Vinylpyrrolidone-vinyl acetate copolymer
CAS-No: 25086-89-9
INCI: PVP/VA Copolymer
Regulatory Status: Kollidon® VA 64 Fine meets current Ph. Eur., USP monograph "Copovidone" and the JPE monograph "Copolyvidone"
Applications: The main application is as soluble binder for granulation and as dry-binder in direct compression technology, as a film-forming agent in sprays and as pore-former in coating and taste-masking applications.
Description: Kollidon® VA 64 Fine is a white or slightly yellowish, free-flowing powder with a faint characteristic odor and practically no taste. 
Solubility: Kollidon VA 64 Fine readily dissolve in all hydrophilic solvents. Solutions of more than 10% concentration can be prepared in water, ethanol, isopropanol, methylene chloride, glycerol and propylene glycol. It is less soluble in ether, cyclic, aliphatic and alicyclic hydrocarbons.

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