Kolliphor® HS 15
The potent nonionic solubilizer
Kolliphor® HS 15 is a potent non-ionic solubilizer and emulsifying agent, with low toxicity. Ideal for solubilizing low-solubility actives in microemulsions, it helps tackle even the toughest solubilization challenges. It is used for manufacturing aqueous parenteral preparations with vitamins A, D, E and K, plus lipophilic APIs such as propanidid, miconazole, alfadolone, alfaxalone, nifedipine, and piroxicam. Kolliphor® HS 15 is soluble in water, ethanol, and 2-propanol. As a solubilizer, it is particularly suitable for parenteral and oral dosage forms, and lends itself well to veterinary formulations.
Why choose Kolliphor® HS 15?
- IID-listed excipient
- Low histamine release for fewer side-effects
- Thermal stability
- Monographed in Ph. Eur. and USP-NF
|Former tradename:||Solutol® HS 15|
|Generic name:||Macrogol 15 Hydroxystearate, Polyoxyl 15 Hydroxystearate|
|Regulatory Status:||Kolliphor® HS 15 conforms to the requirements of the European Pharmacopoeia monograph "Macrogol-15-Hydroxystearate".|
|Applications:||The main application is as nonionic solubilizer for manufacturing of aqueous parenteral preparations.|
|Description:||Kolliphor® HS 15 is a yellowish white paste at room temperature that becomes liquid at approx. 30 °C.|
|Composition:||Kolliphor® HS 15 consists of polyglycol mono- and di-esters of 12-hydroxystearic acid (= lipophilic part) and of about 30% of free polyethylene glycol (= hydrophilic part).The free polyethylene glycol can be determined by HPLC. The method is available on request.|
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