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Excipients for Drug Formulation

Kolliphor® P 338

A polymeric multi-talent suitable for a large variety of applications, i.e. Kolliphor® P 338 can be used as solubilizer, emulsifier and plasticizer.

Kolliphor® P 338 is used primarily as thickening agent and gel former, but also as co-emulsifier and consistency enhancer in creams and liquid emulsions, i.e. intravenous fat emulsions. Owing to its ability to affect viscosity, Kolliphor® P 338 is also suitable as stabilizer for topically administered suspensions. As solubilizing agent maintains the clarity of elixirs and syrups. Moreover, it is also  used as a wetting agent in eye drops, ointments, suppository bases, gels, and as tablet binder and coating. As plasticizer in solid dispersions Kolliphor® P 338 is suitable for use in melt granulation, spray drying and hot melt extrusion processes.

Why choose Kolliphor® P 338

  • Suitable for a broad range of applications
  • Fully approved – the high performance and safety is backed by comprehensive documentation
  • BASF’s unparalleled portfolio of solubilizers and emulsifiers for topical products offers you the perfect solution, whatever the application or formulation type
Product Details
Former tradename: Lutrol® F 108 
Chemical Name: Methyl Oxirane polymer with Oxirane
Compendial Name: Ph. Eur., USP-NF: Poloxamer 338
CAS No.: 9003-11-6
Description: Kolliphor®  P grades are white coarse-grained powders with a waxy consistency. They contain an appropriate quantity of the antioxidant BHT. It is freely soluble in water (opalescent solutions) and ethanol; insoluble in diethyl ether, paraffin and fatty oils.

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Related Process Technologies

Melt Granulation

Melt granulation is a great process option in a formulators' biovailability enhancement arsenal. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation.

Hot Melt Extrusion

Hot-melt extrusion has been used in the plastics & food industries for decades. In the 1980s, BASF became the first company to apply it to the production of pharmaceuticals for enhancing the solubility and bioavailability of poorly soluble actives. Today, HME is an accepted process for creating solid dispersions of APIs.

Physical Mixing

BASF offers a broad portfolio of functional excipients suitable for physical mixing processes.

Spray Drying

Spray drying is an established technology in the pharmaceutical industry to create amorphous, soluble forms of active ingredients. Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. BASF offers a wide range of functional polymers to choose from, along with all other excipients typically used in the formulation.

Related Applications

Creams and Emulsions

BASF offers a broad selection of oils, emulsifiers, viscosity enhancers and solvents to equip the formulator to be able to produce a wide range of lotions, creams and gel emulsions.

Foams

BASF offers wide range of excipients for topical formulations enabling you to create the ideal skin delivery solution for your foam formulation. By extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. Our range of solubilizers support effective delivery of the target API – the number-one priority when designing any dermatological product.

Gels

BASF offers a broad selection of matrix builders, sensory modifiers and solvents to equip you to be able to produce a wide range of topcial gels.

Liquid Dispersions, Solutions & Emulsions

A common way to improve the solubility of active ingredients is to formulate them in a liquid form - i.e. dispersion, solution, suspension or emulsion. Although each approach has its differences, they all share the need for functional excipients. BASF offers a comprehensive range of trusted functional excipients to make them work.

Ointments

BASF offers an extensive portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for ointment formulation. We are committed to maintaining the highest level of quality. Our range of solubilizers and penetration enhancers support effective delivery of the target API - the number-one priority when designing any dermatological product.

Solid Dispersions

In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility & bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

Suppositories

BASF offers a variety of matrix builders, solvents and emulsifiers suitable for suppositories.

Related Solution Platforms

Skin Delivery Platform

The perfect solution for every skincare challenge.

Softgels Platform

Functional solutions for all soft gel parts – fill, shell and coating.

Solubilization Platform

Effective solubilization in solid & liquid dosage forms.

Softgels: Capsule Fill

At BASF we offer a comprehensive range of high quality functional excipients, vitamins and omega-3 fish oils to support you in finding the right capsule fill for your formulation needs. This unique combination of products builds a bridge between dietary supplement and pharmaceutical products.

Related Functionalities

Emulsifiers/Solubilizers

Innovative emulsifiers and solubilizers for all topical challenges.

Gel Formers

High-quality poloxamers for the toughest challenges.

Consistency Factors

BASF’s Kolliwax® portfolio features an extensive selection of oleochemical consistency factors to enhance your formulations. Available as free-flowing powders, free-flowing micro-pearls, and fatty acid mixtures, our consistency factors regulate the viscosity and stability of semi-solid formulations.

Suppositories: Matrix builders

BASF offers a variety of hard fats, waxy solids, PEGs and poloxamers ideal for use as matrix builder and structurants in suppository formulations.

Plasticizing

BASF offers a comprehensive portfolio of plasticizing substances for solid dispersion matrices. BASF plasticizers fulfil the requirements of most important monographs and are based on various chemistries and molecular weights.

Binding

BASF offers the most comprehensive range of binders for any formulator challenge – from formulating highly sensitive drugs to establishing efficient continuous processing.