Excipients for Drug Formulation

Kolliphor® P407

A polymeric multi-talent suitable for a large variety of applications, i.e. as thickening agent and gel former and as a co-emulsifier and viscosity enhancer in creams and liquid emulsions.

Kolliphor® P 407 is used primarily as thickening agent and gel former, as well as co-emulsifier and consistency enhancer in creams and liquid emulsions. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations Kolliphor® P 407 is also used as a polymeric solubilizer. In solid dispersions Kolliphor® P 407 can be used in physical mixing, melt granulation, spray drying and hot melt extrusion processes. Moreover, Kolliphor® P 407 is suitable for the formulation of active substances that show reduced solubility as well as chemical stability as a result of neutralization of gel formulations. Thanks to its ability to affect viscosity, it may also be used as stabilizer for topically administered suspensions and is used in tooth-pastes, gargles and mouthwashes. As dissolution enhancer, lubricant & wetting agent particularly Kolliphor® P 407 is specifically suitable for wet granulation processes.

Why use Kolliphor® P 407?

  • Suitable for a broad range of applications
  • Fully approved – the high performance and safety is backed by comprehensive documentation
  • The high performance and safety of BASF products is backed by comprehensive documentation – so you know you can rely on us
  • BASF’s unparalleled portfolio of solubilizers and emulsifiers for topical products offers you the perfect solution, whatever the application or formulation type
Product Details
Chemical name: Poloxamer
Former trade name: Lutrol® F 127
CAS-No: 9003-11-6
INCI: Poloxamer 407
Regulatory Status: Kolliphor® P 407 meet the requirements of the current USP-NF monographs and European Pharmacopoeia family monograph Poloxamer: Ph. Eur., USP-NF: Poloxamer 407. Kolliphor ® P 407 products are also JPE certified (Japanese Pharmaceutical Excipients): Polyoxyethylene (196) Polyoxylpropylene (67) glycol

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