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Excipients for Drug Formulation

Kolliphor® P407

A polymeric multi-talent suitable for a large variety of applications, i.e. as thickening agent and gel former and as a co-emulsifier and viscosity enhancer in creams and liquid emulsions.

Kolliphor® P 407 is used primarily as thickening agent and gel former, as well as co-emulsifier and consistency enhancer in creams and liquid emulsions. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations Kolliphor® P 407 is also used as a polymeric solubilizer. In solid dispersions Kolliphor® P 407 can be used in physical mixing, melt granulation, spray drying and hot melt extrusion processes. Moreover, Kolliphor® P 407 is suitable for the formulation of active substances that show reduced solubility as well as chemical stability as a result of neutralization of gel formulations. Thanks to its ability to affect viscosity, it may also be used as stabilizer for topically administered suspensions and is used in tooth-pastes, gargles and mouthwashes. As dissolution enhancer, lubricant & wetting agent particularly Kolliphor® P 407 is specifically suitable for wet granulation processes.

Why use Kolliphor® P 407?

  • Suitable for a broad range of applications
  • Fully approved – the high performance and safety is backed by comprehensive documentation
  • The high performance and safety of BASF products is backed by comprehensive documentation – so you know you can rely on us
  • BASF’s unparalleled portfolio of solubilizers and emulsifiers for topical products offers you the perfect solution, whatever the application or formulation type
Product Details
Chemical name: Poloxamer
Former trade name: Lutrol® F 127
CAS-No: 9003-11-6
INCI: Poloxamer 407
Regulatory Status: Kolliphor® P 407 meet the requirements of the current USP-NF monographs and European Pharmacopoeia family monograph Poloxamer: Ph. Eur., USP-NF: Poloxamer 407. Kolliphor ® P 407 products are also JPE certified (Japanese Pharmaceutical Excipients): Polyoxyethylene (196) Polyoxylpropylene (67) glycol

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Related Process Technologies

Melt Granulation

Melt granulation is a great process option in a formulators' biovailability enhancement arsenal. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation.

Hot Melt Extrusion

Hot-melt extrusion has been used in the plastics & food industries for decades. In the 1980s, BASF became the first company to apply it to the production of pharmaceuticals for enhancing the solubility and bioavailability of poorly soluble actives. Today, HME is an accepted process for creating solid dispersions of APIs.

Physical Mixing

BASF offers a broad portfolio of functional excipients suitable for physical mixing processes.

Spray Drying

Spray drying is an established technology in the pharmaceutical industry to create amorphous, soluble forms of active ingredients. Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. BASF offers a wide range of functional polymers to choose from, along with all other excipients typically used in the formulation.

Wet Granulation

BASF offers the key functional materials required to achieve great wet granulation results.

Related Applications

Foams

BASF offers wide range of excipients for topical formulations enabling you to create the ideal skin delivery solution for your foam formulation. By extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. Our range of solubilizers support effective delivery of the target API – the number-one priority when designing any dermatological product.

Liquid Dispersions, Solutions & Emulsions

A common way to improve the solubility of active ingredients is to formulate them in a liquid form - i.e. dispersion, solution, suspension or emulsion. Although each approach has its differences, they all share the need for functional excipients. BASF offers a comprehensive range of trusted functional excipients to make them work.

Solid Dispersions

In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility & bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

Related Solution Platforms

Instant & Modified Release Platform

BASFs rich portfolio of instant and modified release solutions offers an unprecedented range of functionality.

Skin Delivery Platform

The perfect solution for every skincare challenge.

Softgels Platform

Functional solutions for all soft gel parts – fill, shell and coating.

Solubilization Platform

Effective solubilization in solid & liquid dosage forms.

Softgels: Capsule Fill

At BASF we offer a comprehensive range of high quality functional excipients, vitamins and omega-3 fish oils to support you in finding the right capsule fill for your formulation needs. This unique combination of products builds a bridge between dietary supplement and pharmaceutical products.

Related Functionalities

Emulsifiers/Solubilizers

Innovative emulsifiers and solubilizers for all topical challenges.

Viscosity Enhancement

BASF offers a variety of products that enhance the viscosity of your topical formulation.

Gel Formers

High-quality poloxamers for the toughest challenges.

Solubilization Enhancement

BASF offers a comprehensive range of high quality lipids, solvents and solubilizers to enhance solubiliuty and bioavailability of poorly soluble drugs in softgel formulations.