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Excipients for Drug Formulation
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Excipients for Drug Formulation
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Excipients for Drug Formulation

Kolliphor® PS 20

A non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer for pharmaceutical preparations like emulsions and creams, gels and foams as well as softgels

Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are non-ionic surfactants and emulsifiers derived from polyethoxylated sorbitan and stearic or oleic acid. Polysorbates are mainly used as a solubilizer, emulsifier or suspension stabilizer for pharmaceutical application. Depending on the HLB value of the product they can either act as solubilzer or emulsifier.

Why choose Kolliphor® PS 20?

  • Suitable for use as solubilzer, emulsifier or skin penetration enhancer
  • Broad pH range
  • Good skin tolerance
  • Fully approved – quality you can trust

Applications of Kolliphor® PS 20

Product Details
Previous name: Polysorbate 20 PH
CAS-No.: 9005-64-5
Regulatory Status: Ph. Eur, USP/NF: Polysorbate 20
General characterization: Kolliphor® PS 20 is a oily, light yellow to brownish-yellowish, clear or slightly opalescent liquid with a faint odour.
Skin Tolerance: Our Kolliphor® PS types have a good skin tolerance.
Raw material origin: All Kolliphor® PS grades are based on vegetable and synthetic raw materials.

Learn more about Kolliphor® PS 20

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Related Process Technologies

Hot Melt Extrusion

Hot-melt extrusion has been used in the plastics & food industries for decades. In the 1980s, BASF became the first company to apply it to the production of pharmaceuticals for enhancing the solubility and bioavailability of poorly soluble actives. Today, HME is an accepted process for creating solid dispersions of APIs.

Melt Granulation

Melt granulation is a great process option in a formulators' biovailability enhancement arsenal. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation.

Physical Mixing

BASF offers a broad portfolio of functional excipients suitable for physical mixing processes.

Spray Drying

Spray drying is an established technology in the pharmaceutical industry to create amorphous, soluble forms of active ingredients. Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. BASF offers a wide range of functional polymers to choose from, along with all other excipients typically used in the formulation.

Related Applications

Creams and Emulsions

BASF offers a broad selection of oils, emulsifiers, viscosity enhancers and solvents to equip the formulator to be able to produce a wide range of lotions, creams and gel emulsions.

Excipients for Parenteral Use

For our parenteral excipients we provide comprehensive documentation including toxicological assessments, regulatory & quality packages, certificates and more.

Foams

BASF offers wide range of excipients for topical formulations enabling you to create the ideal skin delivery solution for your foam formulation. By extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. Our range of solubilizers support effective delivery of the target API – the number-one priority when designing any dermatological product.

Gels

BASF offers a broad selection of matrix builders, sensory modifiers and solvents to equip you to be able to produce a wide range of topcial gels.

Liquid Dispersions, Solutions & Emulsions

A common way to improve the solubility of active ingredients is to formulate them in a liquid form - i.e. dispersion, solution, suspension or emulsion. Although each approach has its differences, they all share the need for functional excipients. BASF offers a comprehensive range of trusted functional excipients to make them work.

Ointments

BASF offers an extensive portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for ointment formulation. We are committed to maintaining the highest level of quality. Our range of solubilizers and penetration enhancers support effective delivery of the target API - the number-one priority when designing any dermatological product.

Orally Disintegrating Tablets (ODT)

Orally disintegrating tablets (ODT), are an innovative solid oral dosage form that is becoming more and more important in the pharmaceutical market, both for prescription and over-the-counter medications. In contrast to classical tablets, ODTs are specifically designed to disintegrate directly in the patient's mouth.

Solid Dispersions

In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility & bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

Suppositories

BASF offers a variety of matrix builders, solvents and emulsifiers suitable for suppositories.

Topical Polymeric Films

BASF offers a number of film formers and plasticizers for topical formulations enabling you to create the ideal skin delivery solution for your topical polymeric film formulation.

Transdermal Patches

BASF offers a variety of polymeric matrix formers and solvents suitable for transdermal patch formulations.

Related Solution Platforms

Skin Delivery Platform

The perfect solution for every skincare challenge.

Softgels Platform

Functional solutions for all soft gel parts – fill, shell and coating.

Solubilization Platform

Effective solubilization in solid & liquid dosage forms.

Softgels: Capsule Fill

At BASF we offer a comprehensive range of high quality functional excipients, vitamins and omega-3 fish oils to support you in finding the right capsule fill for your formulation needs. This unique combination of products builds a bridge between dietary supplement and pharmaceutical products.