Kolliphor® SLS Fine
A widely used ionic solubilizer and high HLB anionic emulsifier that is suitable for application in liquid dispersions, solutions, emulsions and micro-emulsions to formulate tablets, foams and semi-solids such as creams, lotions and gels. Particularily suitable for direct compression.
Kolliphor® SLS, is manufactured by sulfation of the corresponding fatty alcohol of natural origin and subsequent neutralization with sodium hydroxide. The excipient is characterized by a very high active substance matter and a very low content of inorganic salts and unsulfated fatty alcohols. Kolliphor® SLS Fine is extremely efficient throughout the tabletting process by assisting in drug dissolution and aiding water uptake during disintegration of the end formulation.
Why use Kolliphor® SLS?
- Extremely efficient excipient throughout the tabletting process
- Finer particles for more controlled and efficient solubilization
- Widely used ionic solubilizer and high HLB anionic emulsifier
- Additionally suitable as wetting agent or lubricant
- Suitable for solid, semi-solid dosage forms and foams
- Particularily suitable for direct compression
Multiple functionalities for solid and semi-solid dosage forms
Solubilizer and Emulsifier
Kolliphor® SLS Fine can be used as a solubilizer to enhance the solubility of poorly soluble APIs in both solid and liquid oral dosage forms. Kolliphor® SLS grades are also suitable for semi-solid dosage forms like creams, lotions and gels. Moreover, sodium lauryl sulfate is very broadly used in oral care formulations. The finer particles of Kolliphor® SLS Fine allow a more controlled and efficient solubilization.
Wetting agent in tableting
Due to improved wettability of the tablet, Kolliphor® SLS Fine can reduce tablet disintegration time. For this application often Kolliphor® SLS Fine is more suitable than Kolliphor® SLS. Kolliphor® SLS Fine offers a combination of good lubrication effect together with improved tablet or capsule disintegration properties and facilitates manufacturing of modern solid dosage forms. It is particularily suitable for direct compression.
Special lubricant for tablets
Kolliphor® SLS Fine can be used as tablet lubricant if standard lubricants (i.e. magnesium stearate) are incompatible with the formulation. As lubricant the typical usage concentration of Kolliphor® SLS Fine is 2%.
Kolliphor® SLS Fine offers a combination of good lubrication effect together with improved tablet or capsule disintegration properties and facilitates manufacturing of modern solid dosage forms.
| Product Details | |
| Chemical Name: | Sodium Lauryl Sulfate |
| Former product name: | Texapon® K12 G PH |
| CAS-No: | 151-21-3 |
| Regulatory Status: | Ph. Eur.: Sodium Laurilsulfate USP / NF: Sodium Lauryl Sulfate JP: Sodium Lauryl Sulfate Kolliphor® SLS Fine has a self-affirmed GRAS status. A cosher certificate is available upon request. |
| Raw material origin: | Kolliphor® SLS Fine is based on vegetable and synthetic raw materials |
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