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Excipients for Drug Formulation

Kolliphor® SLS Fine

A widely used ionic solubilizer and high HLB anionic emulsifier that is suitable for application in liquid dispersions, solutions, emulsions and micro-emulsions to formulate tablets, foams and semi-solids such as creams, lotions and gels. Particularily suitable for direct compression.

Kolliphor® SLS, is manufactured by sulfation of the corresponding fatty alcohol of natural origin and subsequent neutralization with sodium hydroxide. The excipient is characterized by a very high active substance matter and a very low content of inorganic salts and unsulfated fatty alcohols. Kolliphor® SLS Fine is extremely efficient throughout the tabletting process by assisting in drug dissolution and aiding water uptake during disintegration of the end formulation.

Why use Kolliphor® SLS?

  • Extremely efficient excipient throughout the tabletting process
  • Finer particles for more controlled and efficient solubilization
  • Widely used ionic solubilizer and high HLB anionic emulsifier
  • Additionally suitable as wetting agent or lubricant
  • Suitable for solid, semi-solid dosage forms and foams
  • Particularily suitable for direct compression

Multiple functionalities for solid and semi-solid dosage forms

Kolliphor® SLS Fine can be used as a solubilizer to enhance the solubility of poorly soluble APIs in both solid and liquid oral dosage forms. Kolliphor® SLS grades are also suitable for semi-solid dosage forms like creams, lotions and gels. Moreover, sodium lauryl sulfate is very broadly used in oral care formulations. The finer particles of Kolliphor® SLS Fine allow a more controlled and efficient solubilization.

Due to improved wettability of the tablet, Kolliphor® SLS Fine can reduce tablet disintegration time. For this application often Kolliphor® SLS Fine is more suitable than Kolliphor® SLS. Kolliphor® SLS Fine offers a combination of good lubrication effect together with improved tablet or capsule disintegration properties and facilitates manufacturing of modern solid dosage forms. It is particularily suitable for direct compression.

Kolliphor® SLS Fine can be used as tablet lubricant if standard lubricants (i.e. magnesium stearate) are incompatible with the formulation. As lubricant the typical usage concentration of Kolliphor® SLS Fine is 2%.

Kolliphor® SLS Fine offers a combination of good lubrication effect together with improved tablet or capsule disintegration properties and facilitates manufacturing of modern solid dosage forms.

Product Details
Chemical Name: Sodium Lauryl Sulfate
Former product name: Texapon® K12 G PH
CAS-No: 151-21-3
Regulatory Status:

Ph. Eur.: Sodium Laurilsulfate

USP / NF: Sodium Lauryl Sulfate

JP: Sodium Lauryl Sulfate

Kolliphor® SLS Fine has a self-affirmed GRAS status. A cosher certificate is available upon request.

Raw material origin: Kolliphor® SLS Fine is based on vegetable and synthetic raw materials

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