Kolliphor® SLS, is manufactured by sulfation of the corresponding fatty alcohol of natural origin and subsequent neutralization with sodium hydroxide. The excipient is characterized by a very high active substance matter and a very low content of inorganic salts and unsulfated fatty alcohols. Kolliphor® SLS Fine is extremely efficient throughout the tabletting process by assisting in drug dissolution and aiding water uptake during disintegration of the end formulation.
Kolliphor® SLS Fine can be used as a solubilizer to enhance the solubility of poorly soluble APIs in both solid and liquid oral dosage forms. Kolliphor® SLS grades are also suitable for semi-solid dosage forms like creams, lotions and gels. Moreover, sodium lauryl sulfate is very broadly used in oral care formulations. The finer particles of Kolliphor® SLS Fine allow a more controlled and efficient solubilization.
Due to improved wettability of the tablet, Kolliphor® SLS Fine can reduce tablet disintegration time. For this application often Kolliphor® SLS Fine is more suitable than Kolliphor® SLS. Kolliphor® SLS Fine offers a combination of good lubrication effect together with improved tablet or capsule disintegration properties and facilitates manufacturing of modern solid dosage forms. It is particularily suitable for direct compression.
Kolliphor® SLS Fine can be used as tablet lubricant if standard lubricants (i.e. magnesium stearate) are incompatible with the formulation. As lubricant the typical usage concentration of Kolliphor® SLS Fine is 2%.
Kolliphor® SLS Fine offers a combination of good lubrication effect together with improved tablet or capsule disintegration properties and facilitates manufacturing of modern solid dosage forms.
|Chemical Name:||Sodium Lauryl Sulfate|
|Former product name:||Texapon® K12 G PH|
Ph. Eur.: Sodium Laurilsulfate
USP / NF: Sodium Lauryl Sulfate
JP: Sodium Lauryl Sulfate
Kolliphor® SLS Fine has a self-affirmed GRAS status. A cosher certificate is available upon request.
|Raw material origin:||Kolliphor® SLS Fine is based on vegetable and synthetic raw materials|
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