Kolliphor^® SLS Fine

A widely used ionic solubilizer and high HLB anionic emulsifier that is suitable for application in liquid dispersions, solutions, emulsions and micro-emulsions to formulate tablets, foams and semi-solids such as creams, lotions and gels. Particularily suitable for direct compression.

Kolliphor^® SLS, is manufactured by sulfation of the corresponding fatty alcohol of natural origin and subsequent neutralization with sodium hydroxide. The excipient is characterized by a very high active substance matter and a very low content of inorganic salts and unsulfated fatty alcohols. Kolliphor^® SLS Fine is extremely efficient throughout the tabletting process by assisting in drug dissolution and aiding water uptake during disintegration of the end formulation.

Why use Kolliphor^® SLS?

Extremely efficient excipient throughout the tabletting process
Finer particles for more controlled and efficient solubilization
Widely used ionic solubilizer and high HLB anionic emulsifier
Additionally suitable as wetting agent or lubricant
Suitable for solid, semi-solid dosage forms and foams
Particularily suitable for direct compression

Multiple functionalities for solid and semi-solid dosage forms

Solubilizer and Emulsifier

Kolliphor^® SLS Fine can be used as a solubilizer to enhance the solubility of poorly soluble APIs in both solid and liquid oral dosage forms. Kolliphor^® SLS grades are also suitable for semi-solid dosage forms like creams, lotions and gels. Moreover, sodium lauryl sulfate is very broadly used in oral care formulations. The finer particles of Kolliphor^® SLS Fine allow a more controlled and efficient solubilization.

Wetting agent in tableting

Due to improved wettability of the tablet, Kolliphor^® SLS Fine can reduce tablet disintegration time. For this application often Kolliphor^® SLS Fine is more suitable than Kolliphor^® SLS. Kolliphor^® SLS Fine offers a combination of good lubrication effect together with improved tablet or capsule disintegration properties and facilitates manufacturing of modern solid dosage forms. It is particularily suitable for direct compression.

Special lubricant for tablets

Kolliphor^® SLS Fine can be used as tablet lubricant if standard lubricants (i.e. magnesium stearate) are incompatible with the formulation. As lubricant the typical usage concentration of Kolliphor^®SLS Fine is 2%.

Kolliphor^® SLS Fine offers a combination of good lubrication effect together with improved tablet or capsule disintegration properties and facilitates manufacturing of modern solid dosage forms.

Product Details
Chemical Name:	Sodium Lauryl Sulfate
Former product name:	Texapon^®K12 G PH
CAS-No:	151-21-3
Regulatory Status:	Ph. Eur.: Sodium Laurilsulfate USP / NF: Sodium Lauryl Sulfate JP: Sodium Lauryl Sulfate Kolliphor^® SLS Fine has a self-affirmed GRAS status. A cosher certificate is available upon request.
Raw material origin:	Kolliphor^® SLS Fine is based on vegetable and synthetic raw materials

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Related Process Technologies

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Direct Compression

Direct compression (DC) is the most economic way to produce a tablet as it is the shortest and most direct way to get from powder mix to final dosage form. BASF offers all functional excipients to successfully develop a DC process for your drug, including key elements like appropriate binder and lubricant.

Dry Granulation

Dry granulation is a great choice to produce solid oral dosage forms if cost and process efficiency are essiential. BASF offers the most effective dry binders available, along with all other functional materials and expertise required to help you develop your process successfully.

Related Applications

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Foams

BASF offers wide range of excipients for topical formulations enabling you to create the ideal skin delivery solution for your foam formulation. By extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. Our range of solubilizers support effective delivery of the target API – the number-one priority when designing any dermatological product.

Solid Dispersions

In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility & bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

Instant & Modified Release Platform

BASFs rich portfolio of instant and modified release solutions offers an unprecedented range of functionality.

Skin Delivery Platform

The perfect solution for every skincare challenge.

Kolliphor® SLS Fine