Excipients for Drug Formulation

Kolliphor® SLS

A widely used ionic solubilizer & and high HLB anionic emulsifier that is suitable for application in liquid dispersions, solutions, emulsions and micro emulsions to formulate tablets, foams and semi-solids such as creams, lotions and gels.

Kolliphor® SLS, is manufactured by sulfation of the corresponding fatty alcohol of natural origin and subsequent neutralization with sodium hydroxide. The excipient is characterized by a very high active substance matter and a very low content of inorganic salts and unsulfated fatty alcohols. Kolliphor® SLS is extremely efficient throughout the tableting process by assisting in drug dissolution and aiding water uptake during disintegration of the end formulation.

Why use Kolliphor® SLS?

  • Extremely efficient excipient throughout the tableting process
  • Widely used ionic solubilizer and high HLB anionic emulsifier
  • Additionally suitable as wetting agent or lubricant
  • Suitable for solid, semi-solid dosage forms and foams

Multiple functionalities for solid and semi-solid dosage forms

Kolliphor® SLS can be used as a solubilizer to enhance the solubility of poorly soluble APIs in both solid and liquid oral dosage forms. Kolliphor® SLS grades are also suitable for semi solid dosage forms like creams, lotions and gels. Moreover, sodium lauryl sulfate is very broadly used in oral care formulations. Kolliphor® SLS can be used in physical mixing, melt granulation, spray drying and hot melt extrusion processes.

Due to improved wettability of the tablet, Kolliphor® SLS can reduce tablet disintegration time.


Kolliphor® SLS can be used as tablet lubricant if standard lubricants (i.e. magnesium stearate) are incompatible with the formulation. As lubricant the typical usage concentration of Kolliphor® SLS is 2%.

Product Details
Chemical Name: Sodium Lauryl Sulfate
Former product name: Texapon® K12 G PH
CAS-No: 151-21-3
Regulatory Status:

Ph. Eur.: Sodium Laurilsulfate
USP / NF: Sodium Lauryl Sulfate
JP: Sodium Lauryl Sulfate

Kolliphor® SLS has a self-affirmed GRAS status. A cosher certificate is available upon request.

Raw material origin: Kolliphor® SLS is based on vegetable and synthetic raw materials

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Kolliphor® SLS

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