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Excipients for Drug Formulation

Kollisolv® PYR

Solvent for injectables and oral formulations for animal health.

Kollisolv® PYR (2-Pyrrolidone) is approved for the use in veterinary medicines. The product is mainly used as a solvent for intravenous applications or topical preparations. It has also been suggested for use in human pharmaceutical formulations as solvent in parenteral, oral, and topical applications. In topical applications, Kollisolv® PYR appears to be effective penetration enhancer. Pyrrolidone has also been investigated for their application in controlled-release depot formulations. Kollisolv® PYR shows strong antimicrobial effectiveness against gram-positive and gram-negative bacteria and moulds. This results in additional preservation of the application formulation possibly no longer being necessary.

Benefits of Kollisolv® PYR

  • Approved solvent for veterinary use in injectables & oral formulations
  • Versatile solvent with broad miscibility for topical application
  • Rigorously tested – ensuring exceptional quality

Major Applications of Kollisolv® PYR

Kollisolv® PYR is used in veterinary injection preparations as a solvent together with water and/or in combination with low molecular polyvinylpyrrolidone (Kollidon® 12 PF or Kollidon® 17 PF). Likewise it suggests itself for use in solutions for oral application.

A number of scientific publications describe the application of Kollisolv® PYR as absorption enhancer in topical preparations. The penetration of active ingredients through the human skin is markedly increased by Kollisolv® PYR and/or accelerated to the same extend as by dimethyl sulphoxide, dimethyl isosorbide or dimethyl acetamide or even more markedly than by means of dimethyl formamide. This effect is also described for transdermal systems and for the transmucosal application.

Product Details
Chemical name: 2-Pyrrolidone
Former product name: Soluphor® P
CAS-No: 616-45-5
Regulatory status: Ph. Eur., USP / NF, JP: Pyrrolidone

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