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Excipients for Drug Formulation

Kolliwax® HCO - Truly one of a kind!

Kolliwax® HCO is hydrogenated castor powder for pharmaceutical application used as consistency factor in topical formulations, as lipohphillic lubricant in tablets and capsules and as plasticizer in solid dispersions using spray drying, melt granulation or hot melt extrusion processes. Kolliwax® HCO is particularily suitable for formulation of sensitive APIs.

Kolliwax® HCO hydrogenated castor oil complies with IPEC GMP standards for critical pharmaceutical applications. It is used as a consistency factor in topical formulations, as alipophillic lubricant in tablets and capsules, and as a plasticizer in solid dispersions using spray drying, melt granulation or hot melt extrusion processes. It ensures risk reduction in pharmaceutical applications and meets all relevant regulatory needs. Kolliwax® HCO commercial packaging includes a transport friendly and secure box with primary electrostatically dissipative PE packaging material.

Why choose Kolliwax® HCO?

  • IPEC GMP compliant and Secure Lined Box Packaging
  • Unique particle size distribution
  • Is particularly suitable for the formulation of sensitive APIs
  • Compatible with several natural vegetable and animal waxes, as well as fatty alcohols to enhance viscosity of topical formulations
  • Suitable as a plasticizer for melt granulation, spray drying, hot melt extrusion
  • Compatible with several APIs, no metallic taste, effective lubricant

Applications of Kolliwax® HCO

In topical formulations, Kolliwax® HCO can be used as consistency factor to enhance the viscosity of the formulation. The typical concentration at about 0.1-2% hydrogenated castor oil is compatible with most natural vegetable and animal waxes and can therefore be used in combination with fatty alcohols and other consistency factors.

Similar to emollients, waxes affect the sensory profile and the stability of a topical formulation. They are solid at ambient temperatures and stabilize emulsions as the viscosity is increased by formation of lamellar structures in oil-in-water formulations.

Furthermore Kolliwax® HCO has a special advantage because of its high melting point and is able to support the formulation stability particularly at elevated temperatures.

Lubricants prevent ingredients from clumping together and from sticking to the tablet punches or capsule filling machine. Lubricants also ensure that tablet formulations and ejection can occur with low friction. Common minerals like talc or silica, and fats, e.g. vegetable stearin, magnesium stearate or stearic acid, are most frequently used lubricants in tablets or hard gelatin capsules. Lubricants are added in small quantities to tablet or capsule formulations to improve certain processing characteristics.

In tablet formulations Kolliwax® HCO can be used as a lubricant as an effective alternative to magnesium stearate. Hydrogenated castor oil is compatible to a large number of actives and does not provide a metallic taste. Kolliwax® HCO is particularly suitable for formulation of sensitive APIs.

In solid dispersions, Kolliwax® HCO is used as plasticizer in solid polymeric matrices. It is suitable for melt granulation, spray drying and hot melt extrusion processes.

Regulatory Status

Ph. Eur.: Castor Oil Hydrogenated, USP/NF: Hydrogenated Castor Oil, JP: Hydrogenated Oil

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