Kolliwax^® SA

As lipophilic lubricant Kolliwax^®SA is the first choice for sensitive acidic APIs. It is commonly also used as viscosity regulator for oil-in-water emulsions and as a pH independent sustained release agent. Kolliwax^®SA acts as a plasticizer with included consistency factor in solid dispersions. It hardens suppository formulations and adjust their melting points.

Why choose Kolliwax^® SA?

Fully approved pharmaceutical-grade excipient – for your peace of mind
Pasticizer with included consistency factor functionality
Lipophilic lubricant and the first choice for sensitive acidic APIs
Viscosity regulator with a higher melting point
Guaranteed performance across a wide variety of applications
Innovative solutions for better, more stable formulations

Major Applications of Kolliwax^® SA

Emulsions

Kolliwax^® grades can be used for all kinds of topical pharmaceutical applications such as gels, lotions and creams. All Kolliwax^® grades act as consistency factors and co-emulsifiers at the same time. With their amphiphilic structure they will stabilize the surface between oil and water and will help to enhance the viscosity with building up a liquid crystalline network in the water-phase (lamellar structure).

Kolliwax^® SA is able to stabilize W/O and O/W emulsion and will help top create a unique softness and creaminess in the end application. Kolliwax^® SA is mainly used as structure-building consistency factor for semi-solids such as creams, emulsions, ointments and gels as well as a viscosity regulator with a higher melting point.

Lubricantion

Kolliwax^® SA is a lipophilic lubricant and the first choice for sensitive acidic APIs. As solid lubricant it is suitable for direct compression, wet granulation and roll compaction of tablets and capsules.

Plasticizer

In solid dispersions, Kolliwax^® SA also acts as plasticizer with an included consistency factor functionality. It is suitable for melt granulation, spray drying and hot melt extrusion (HME) processes.

Suppository masses

Suppository formulations can be hardened and adjusted in their melting point by the addition of Kolliwax^® SA.

Product Details
Chemical name	Stearyl Alcohol
Former product name	Speziol^® C 18 Pharma
CAS No	112-92-5
Raw material origin	Kolliwax^® SA is based on vegetable and synthetic raw materials.
Regulatory status	Ph. Eur., USP / NF, JP: Stearyl Alcohol

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Related Production Technologies

Hot Melt Extrusion

Hot-melt extrusion has been used in the plastics & food industries for decades. In the 1980s, BASF became the first company to apply it to the production of pharmaceuticals for enhancing the solubility and bioavailability of poorly soluble actives. Today, HME is an accepted process for creating solid dispersions of APIs.

Melt Granulation

Melt granulation is a great process option in a formulators' biovailability enhancement arsenal. A meltable binder is used to agglomerate drug and other ingredients to reduce recrystallization potential through separation. BASF offer all functional materials required for a successful formulation using melt granulation.

Spray Drying

Spray drying is an established technology in the pharmaceutical industry to create amorphous, soluble forms of active ingredients. Key for a successful process is the use of the right functional polymer to ensure a stable solid dispersion. BASF offers a wide range of functional polymers to choose from, along with all other excipients typically used in the formulation.

Direct Compression

Direct compression (DC) is the most economic way to produce a tablet as it is the shortest and most direct way to get from powder mix to final dosage form. BASF offers all functional excipients to successfully develop a DC process for your drug, including key elements like appropriate binder and lubricant.

Dry Granulation

Dry granulation is a great choice to produce solid oral dosage forms if cost and process efficiency are essiential. BASF offers the most effective dry binders available, along with all other functional materials and expertise required to help you develop your process successfully.

Wet Granulation

BASF offers the key functional materials required to achieve great wet granulation results.

Related Applications

Creams and Emulsions

BASF offers a broad selection of oils, emulsifiers, viscosity enhancers and solvents to equip the formulator to be able to produce a wide range of lotions, creams and gel emulsions.

Foams

BASF offers wide range of excipients for topical formulations enabling you to create the ideal skin delivery solution for your foam formulation. By extensively analyzing, refining and enhancing the sensorial effects of each ingredient class, we can help you to create products that increase patient compliance. We are committed to maintaining the highest level of quality. At the same time, we have focused on improving the mildness of formulations. Our range of solubilizers support effective delivery of the target API – the number-one priority when designing any dermatological product.

Gels

BASF offers a broad selection of matrix builders, sensory modifiers and solvents to equip you to be able to produce a wide range of topcial gels.

Ointments

BASF offers an extensive portfolio of excipients for topical formulations enabling you to create the ideal skin delivery solution for ointment formulation. We are committed to maintaining the highest level of quality. Our range of solubilizers and penetration enhancers support effective delivery of the target API - the number-one priority when designing any dermatological product.

Solid Dispersions

In a solid dispersion the drug is dispersed in a carrier with the system appearing to be in a solid state. Target is an increase in solubility & bioavailability. BASF offers both an comprehensive portfolio and process expertise to consult you in finding the best formulation for your poorly soluble drug using a solid dispersions.

Suppositories

BASF offers a variety of matrix builders, solvents and emulsifiers suitable for suppositories.

Instant & Modified Release Platform

BASFs rich portfolio of instant and modified release solutions offers an unprecedented range of functionality.

Skin Delivery Platform

The perfect solution for every skincare challenge.

Solubilization Platform

Effective solubilization in solid & liquid dosage forms.

Related Functionalities

Lubrication

BASF offers a comprehensive range of lubricants, particularly for sensitive active ingredients.

Consistency Factors

BASF’s Kolliwax^® portfolio features an extensive selection of oleochemical consistency factors to enhance your formulations. Available as free-flowing powders, free-flowing micro-pearls, and fatty acid mixtures, our consistency factors regulate the viscosity and stability of semi-solid formulations.

Viscosity Enhancement

BASF offers a variety of products that enhance the viscosity of your topical formulation.

Sustained Release

Sustained release profiles allow tailored dosing of the active ingredient over an extended period of time up to 24 hours. Common ways to achieve such release rates are the use of film coating, a sustained release matrix or sustained release drug-loaded granules. BASF offers powerful excipients that provide almost endless design space for sustained release formulations.

Plasticizing

BASF offers a comprehensive portfolio of plasticizing substances for solid dispersion matrices. BASF plasticizers fulfil the requirements of most important monographs and are based on various chemistries and molecular weights.

Suppositories: Matrix builders

BASF offers a variety of hard fats, waxy solids, PEGs and poloxamers ideal for use as matrix builder and structurants in suppository formulations.

Kolliwax® SA

Why choose Kolliwax® SA?

Major Applications of Kolliwax® SA